• Modeling and simulation of the "IL-36 cytokine" and CAR-T cells interplay in cancer onset 

  Al-Utaibi, Khaled Abdul-Aziz; Nutini, Alessandro; Sohail, Ayesha; Arif, Robia; Tunç, Sümeyye; Sait, Sadiq M. (World Scientific, 2022)

  Background: CAR-T cells are chimeric antigen receptor (CAR)-T cells; they are target-specific engineered cells on tumor cells and produce T cell-mediated antitumor responses. CAR-T cell therapy is the "first-line" therapy ...

• Potential of novel methyl jasmonate analogs as anticancer agents to metabolically target HK-2 activity in glioblastoma cells 

  Uludağ, Damla; Bay, Sadık; Onur Sucu, Bilgesu; Şavluğ İpek, Özgecan; Mohr, Thomas; Güzel, Mustafa; Karakaş, Nihal (Frontiers Media S.A., 2022)

  Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, ...

• Reactivity of posterior cortical electroencephalographic alpha rhythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and Lewy body diseases 

  Babiloni, Claudio; Lorenzo, Ivan; Lizio, Roberta; Lopez, Susanna; Tucci, Federico; Ferri, Raffaele; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Onofrj, Marco; Stocchi, Fabrizio; Vacca, Laura; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Aarsland, Dag; Parnetti, Lucilla; Marizzoni, Moira; D'Antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lütfü; Yener, Görsev; Hünerli Gündüz, Duygu; Taylor, John Paul; Schumacher, Julia; McKeith, Ian; Frisoni, Giovanni B.; De Pandis, Maria Francesca; Bonanni, Laura; Percio, Claudio Del; Noce, Giuseppe (Elsevier Inc., 2022)

  Please modify the Abstract as follows:Here we tested if the reactivity of posterior resting-state electroencephalographic (rsEEG) alpha rhythms from the eye-closed to the eyes-open condition may differ in patients with ...

• Ürün tanıtım temsilcilerinin yeterlilik eğitimindeki başarı düzeylerinin demografik özellikleriyle karşılaştırılması 

  Düzcü, Tuba; Akyol, Mesut; Sancar, Oya (Hacettepe Üniversitesi, 2017)

  Tıbbi mümessiller ile ilgili ulusal ve uluslararası yapılan çalışmalar incelendiğinde; çalışmaların kısıtlı sayıdaki tıbbi mümessiller ile yapıldıkları ve tıbbi mümessil profilini yeterli düzeyde yansıtmadığı görülmüştür. ...

• Mechanistic insight into impact of phosphorylation on dynamics of farnesyltransferase: Targeting the protein under hyperinsulinemia 

  Pekel, Hanife; Güzel, Mustafa; Şensoy, Özge (Cell Press, 2022)

  ...

• Therapeutic role of repetitive transcranial magnetic stimulation in Alzheimer's and Parkinson's disease: Electroencephalography microstate correlates 

  Hanoğlu, Lütfü; Toplutaş, Eren; Sarıçaoğlu, Mevhibe; Velioğlu, Halil Aziz; Yıldız, Sultan; Yuluğ, Burak (Frontiers Media SA, 2022)

  Introduction: The microstate analysis is a method to convert the electrical potentials on the multi-channel electrode array to topographical electroencephalography (EEG) data. Repetitive transcranial magnetic stimulation ...

• Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines 

  Onur Sucu, Bilgesu; Koç, Elif Beyza; Şavluğ İpek, Özgecan; Mirat, Afranur; Almas, Furkan; Güzel, Melike Aybala; Doğan, Berna; Uludağ, Damla; Karakaş, Nihal; Durdağı, Serdar; Güzel, Mustafa (Elsevier Inc., 2022)

  Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of ...

• Antileishmanial activity of BNIPdaoct- and BNIPdanon-loaded emulsomes on leishmania infantum parasites 

  İşlek, Zeynep; Üçışık, Mehmet Hikmet; Keskin, Elif; Onur Sucu, Bilgesu; Gomes-Alves, Ana G.; Tomás, Ana M.; Güzel, Mustafa; Şahin, Fikrettin (Frontiers Media S.A., 2022)

  Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on ...

• Protective effect of edaravone on rat testis after valproic acid treatment 

  Çelik, Çağrı; Bayrak, Bertan Boran; Hacıhasanoğlu Çakmak, Neziha; Yanardağ, Refiye (Marmara University, 2022)

  Valproic acid n-dipropyl-acetic acid, VPA) is a medication used as anticonvulsant in the treatment of bipolar disorder, and for migraine prophylaxis. Long-term use of VPA is known to trigger reproductive impairment, which ...

• Üniversite öğrencilerinde tütün kullanım alışkanlıklarının belirleyicileri ve algılar: İstanbul ilinde sağlık hizmetleri yüksekokulu öğrencileri örneği 

  Güdük, Özden; Selimoğlu Namoğlu, Selda; Yemenici, Merve; Ertürk, Nazlı; Arğa, Kazım Yalçın; Doğan Merih, Yeliz; Satman, İlhan (Atatürk Üniversitesi, 2021)

  Amaç: Sağlık Meslek Yüksekokulu öğrencilerinin tütün ve tütün ürünleri kullanma davranışlarını incelemek ve bu davranış üzerinde belirleyicifaktörleri ortaya koymaktır.Yöntem: Bu araştırma, Medipol Üniversitesi Sağlık ...

• Novel β‑hydroxy ketones: Synthesis, spectroscopic characterization, molecular docking, and anticancer activity studies 

  Başpınar Küçük, Hatice; Kantürk, Gökhan; Yerlikaya, Şerife; Yıldız, Tülay; Şentürk, Ahmet Mesut; Güzel, Mustafa (Elsevier B. V., 2022)

  In this study, a series of novel β‑hydroxy ketone derivatives 3a-o were designed, synthesized, and evaluated for their anticancer activity. The structure of these compounds were characterized by IR, 1H and 13C NMR, mass ...

• The multifactorial role of pre-supplementary motor area stimulation in the freezing of gait: An alternative strategy to the classical drug-Target approach 

  Sarıcaoğlu, Mevhibe; Hanoğlu, Lütfü; Toprak, Güven; Helvacı Yılmaz, Nesrin; Yuluğ, Burak (Bentham Science Publishers, 2021)

  Introduction: The pre-supplementary motor area (Pre-SMA) plays a pivotal role in the control of voluntary motor control and freezing of gait (FOG) pathophysiological mechanism. Here, we aimed to modulate if the pre-SMA ...

• The effects of edaravone, a free-radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters 

  Bayrak, Bertan Boran; Yılmaz, Sebahat; Hacıhasanoğlu Çakmak, Neziha; Yanardağ, Refiye (Wiley, 2021)

  In this study, we aimed to evaluate whether edaravone (EDA) has a protective role against valproic acid (VPA)-induced lung damage via its antioxidative activity. Male Sprague-Dawley rats were split into four groups. Control ...

• Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro 

  Ferreira, Juliana C.; Fadl, Samar; İlter, Metehan; Pekel, Hanife; Rezgui, Rachid; Şensoy, Özge; Rabeh, Wael M. (John Wiley and Sons Inc, 2021)

  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global pandemics of the modern era. Potential treatment strategies against ...

• Antiproliferative properties and structural analysis of newly synthesized Schiff bases bearing pyrazole derivatives and molecular docking studies 

  Şener, Nesrin; Özkınalı, Sevil; Çelik Altunoğlu, Yasemin; Yerlikaya, Şerife; Gökçe, Halil; Zurnacı, Merve; Gür, Mahmut; Baloğlu, Mehmet Cengiz; Şener, İzzet (Elsevier, 2021)

  New pyrazole Schiffbases containing azo groups were synthesized using the condensation reaction between p-nitrobenzaldehyde and (E)-4-(phenyl)-1-H-pyrazole-3,5-diamine in the molar ratio of 1:2. Characterization of the ...

• Transforaminal epidural steroid injection for recurrent lumbar disc herniation 

  Yüce, İsmail; Kahyaoğlu, Okan; Ataseven, Müzeyyen; Çavuşoğlu, Halit; Aydın, Yunus (Formerly Turgut Özal Medical Center, 2020)

  Aim: Transforaminal epidural steroid injection reduces the low back-leg pain which caused by lumbar disc herniation (LDH). The aim of our study is to evaluate the treatment of transforaminal epidural steroid injection for ...

• Effect of stretching exercises in individuals with piriformis syndrome 

  Ergezen, G. E. (Springer London Ltd, 2020)

  ...

• Evaluation of antidiabetic activities of scorzonera species on alloxan-induced diabetic mice 

  Şakul, Ayşe Arzu; Kurtul, Ekin; Özbek, Hanefi; Kırmızı, Neriman İpek; Bahtiyar, Bade Cevriye; Saltan, Hayriye; Bahadır Acıkara, Özlem (Marmara University Faculty of Health Sciences, 2021)

  Objective: In Turkish folk medicine, different species of Scorzonera (Asteraceae) have been used in the treatment of various disorders. The study aimed to investigate antidiabetic activity of Scorzonera species and if rutin ...

• Surgical treatment and outcomes of intramedullary tumors by minimally invasive approach 

  Yüce, İsmail; Kahyaoǧlu, Okan; Çavuşoğlu, Halit Arda; Ataseven, Müzeyyen; Çavuşoǧlu, Halit; Aydın, Yunus (Churchill Livingstone, 2021)

  Intramedullary tumors are uncommon neoplasms which, without treatment, can cause neurologic morbidity or mortality. The goal of the treatment is complete surgical resection with a minimally invasive approach while preserving ...

• A single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasma 

  Gemici, Aliihsan; Bilgen, Hülya; Erdoğan, Cem; Kansu, Abdullah; Olmuşçelik, Oktay; Beköz, Hüseyin Saffet; Dinleyici, Rümeysa; Mert, Ali; Sevindik, Ömür Gökmen (Tübitak Scientific & Technical Research Council Turkey, 2020)

  Background/aim: A SARS-Cov2 infection which was first arised from Wuhan in December 2019 and named as COVID-19. Still there lacks either a specific treatment or a vaccine to treat COVID-19. Convalescent plasma (CP) was ...

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