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dc.contributor.authorBademci, Refik
dc.contributor.authorErdoğan, Mümin Alper
dc.contributor.authorEroğlu, Ersan
dc.contributor.authorMeral, Ayfer
dc.contributor.authorErdoğan, Arife
dc.contributor.authorAtasoy, Özüm
dc.contributor.authorErbaş, Oytun
dc.date.accessioned2021-12-22T08:27:01Z
dc.date.available2021-12-22T08:27:01Z
dc.date.issued2021en_US
dc.identifier.citationBademci, R., Erdoğan, M. A., Eroğlu, E., Meral, A., Erdoğan, A., Atasoy, Ö. ... Erbaş, O. (2021). Demonstration of the protective effect of ghrelin in the livers of rats with cisplatin toxicity. Human and Experimental Toxicology, 40(12), 2178-2187. https://doi.org/10.1177/09603271211026722en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.urihttps://doi.org/10.1177/09603271211026722
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8709
dc.description.abstractDespite the various and newly developed chemotherapeutic agents in recent years, cisplatin is still used very frequently as a chemotherapeutic agent, even though cisplatin has toxic effects on many organs. The aim of our study is to show whether ghrelin reduces the liver toxicity of cisplatin in the rat model. Twenty-eight male Sprague Dawley albino mature rats were chosen to be utilized in the study. Group 1 rats (n = 7) were taken as the control group, and no medication was given to them. Group 2 rats (n = 7) received 5 mg/kg/day cisplatin and 1 ml/kg/day of 0.9% NaCl, Group 3 rats (n = 7) received 5 mg/kg/day cisplatin and 10 ng/kg/day ghrelin, Group 4 rats (n = 7) received 5 mg/kg/day cisplatin and 20 ng/kg/day ghrelin for 3 days. Glutathione, malondialdehyde (MDA), superoxide dismutase (SOD), plasma alanine aminotransferase (ALT) levels, and liver biopsy results were measured in rats. It was determined that, especially in the high-dose group, the MDA, plasma ALT, and SOD levels increased less in the ghrelin group as compared to the cisplatin group, and the glutathione level decreased slightly with a low dose of ghrelin, while it increased with a higher dose. In histopathological examination, it was determined that the toxic effect of cisplatin on the liver was reduced with a low dose of ghrelin, and its histopathological appearance was similar to normal liver tissue when given a high dose of ghrelin. These findings show that ghrelin, especially in high doses, can be used to reduce the toxic effect of cisplatin.en_US
dc.language.isoengen_US
dc.publisherSAGE Publications Inc.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatotoxicityen_US
dc.subjectCisplatinen_US
dc.subjectGhrelinen_US
dc.subjectAntioxidanten_US
dc.subjectToxicityen_US
dc.titleDemonstration of the protective effect of ghrelin in the livers of rats with cisplatin toxicityen_US
dc.typearticleen_US
dc.relation.ispartofHuman and Experimental Toxicologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.authorid0000-0001-9378-4438en_US
dc.identifier.volume40en_US
dc.identifier.issue12en_US
dc.identifier.startpage2178en_US
dc.identifier.endpage2187en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1177/09603271211026722en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.scopusqualityQ2en_US


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