The creation of unilateral intermittent and unintermittent renal ischemia-reperfusion models in rats
Göster/ Aç
Erişim
info:eu-repo/semantics/openAccessAttribution-NonCommercial-ShareAlike 4.0 Internationalhttps://creativecommons.org/licenses/by-nc-sa/4.0/Tarih
2021Yazar
Soytaş, MustafaGürsoy, Duygu
Boz, Mustafa Yücel
Çakıcı, Çağrı
Keskin, İlknur
Yiğitbaşı, Türkan
Güven, Selçuk
Horuz, Rahim
Albayrak, Selami
Üst veri
Tüm öğe kaydını gösterKünye
Soytaş, M., Gürsoy, D., Boz, M. Y., Çakıcı, Ç., Keskin, İ., Yiğitbaşı, T. ... Albayrak, S. (2021). The creation of unilateral intermittent and unintermittent renal ischemia-reperfusion models in rats. Urology Annals, 13(4), 378-383. https://dx.doi.org/10.4103/UA.UA_79_20Özet
Background and Aim: This study aims to establish unilateral intermittent and unintermittent partial nephrectomy-like renal ischemia-reperfusion (I-R) model in rats and to compare the results with biochemical findings. Material and Methods: The study was conducted on 24 adult 8-week-old male Wistar-Albino rats, each weighing s200-250 g. The rats were divided into three groups. In the Sham group (n = 8), the kidney was surgically exposed and closed. We designed experimental I-R models in the second group (n = 8, a total of 30-min ischemia model in the manner of 3 intermittent sets 8 minutes clamping and 2 min unclamping) and in the third group (n = 8, one session of 30-min unintermittent ischemia). In postoperative day 1, the rats were sacrificed, and the effects of I-R models on the renal tissue were comparatively assessed by evaluating serum Neutrophil Gelatinase-Associated Lipocalin (NGAL), serum kidney injury molecule-1 (KIM-1), urinary NGAL, urinary KIM-1, and serum creatinine levels. Results: Urinary NGAL and KIM-1 levels were significantly higher in the continuous ischemia group when compared to those in the sham and intermittent ischemia groups (P < 0.05). In the intermittent ischemia group, urinary NGAL and urinary KIM-1 levels were significantly higher than those in the sham group (P < 0.05). Although the results of serum NGAL, serum KIM-1, and serum creatinine levels seemed to be in parallel to the results of urinary markers, no statistically significant difference was found. Conclusion: Renal injury was significantly less in the intermittent I-R model when compared to that in the unintermittent I-R model in our experimental rat study.
Scopus Q Kategorisi
Q3Kaynak
Urology AnnalsCilt
13Sayı
4Koleksiyonlar
- Makale Koleksiyonu [3804]
- PubMed İndeksli Yayınlar Koleksiyonu [4268]
- Scopus İndeksli Yayınlar Koleksiyonu [6632]
- WoS İndeksli Yayınlar Koleksiyonu [6705]