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dc.contributor.authorÖzbek, Merve
dc.contributor.authorOdabaşı, Mahmut
dc.contributor.authorKaraman Erdur, Sevil
dc.contributor.authorŞentürk, Fevzi
dc.contributor.authorÖzsütçü, Mustafa
dc.contributor.authorAras, Cengiz
dc.date.accessioned2021-11-02T11:35:39Z
dc.date.available2021-11-02T11:35:39Z
dc.date.issued2021en_US
dc.identifier.citationÖzbek, M., Odabaşı, M., Karaman Erdur, S., Şentürk, F., Özsütçü, M. ve Aras, C. (2021). Determination of the retinal toxicity of intravitreal colistin in rabbit eyes. Cutaneous and Ocular Toxicology, 40(4), 300-304. https://dx.doi.org/10.1080/15569527.2021.1945617en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.urihttps://dx.doi.org/10.1080/15569527.2021.1945617
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8545
dc.description.abstractPurpose To determine the possible adverse effects and safe dose range of intravitreal colistin, an antibiotic, after its intravitreal application. Methods Twenty eyes of 20 adult male and female New Zealand white rabbits were selected. Various concentrations of colistin were prepared. In each rabbit, 0.1 mL of colistin solution or saline solution was injected intravitreally into the right eye. Electroretinographic recordings were taken before and 2 weeks after injection. Histopathological examination was made using a light microscope following enucleation and fixation procedures. In histopathologic cross-sections, the differences between drug-injected eyes and control eyes were evaluated. Results Electroretinographic examination showed a decrease of 30% as a significant value in the a and b wave amplitudes of the rabbits that injected 400 mu g/0.1 ml and higher concentrations. Histological examination revealed histiocytic infiltration, histiocytic vacuoles, inflammation, and retinal degeneration in rabbit eyes given 400 mu g/0.1 ml, 800 mu g/0.1 ml, and 1.6 mg/0.1 ml concentrations of colistin. Conclusion Based on our findings, the safe concentration of colistin is 0.2 mg/0.1 ml. Administration of 0.4 mg/0.1 ml was associated with cataract development, electrophysiological depression, and pathological changes in retinal layers.en_US
dc.language.isoengen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectColistinen_US
dc.subjectElectroretinographyen_US
dc.subjectEndophthalmitisen_US
dc.subjectIntravitreal Injectionen_US
dc.subjectRetinal Toxicityen_US
dc.titleDetermination of the retinal toxicity of intravitreal colistin in rabbit eyesen_US
dc.typearticleen_US
dc.relation.ispartofCutaneous and Ocular Toxicologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-6408-2709en_US
dc.authorid0000-0001-9829-7268en_US
dc.authorid0000-0002-8851-6559en_US
dc.authorid0000-0001-8954-5055en_US
dc.authorid0000-0002-8047-5553en_US
dc.identifier.volume40en_US
dc.identifier.issue4en_US
dc.identifier.startpage300en_US
dc.identifier.endpage304en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1080/15569527.2021.1945617en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ3en_US


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