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dc.contributor.authorSoran, Atilla
dc.contributor.authorDoğan, Lütfi
dc.contributor.authorIşık, Arda
dc.contributor.authorÖzbaş, Serdar
dc.contributor.authorCan Trabulus, Didem
dc.contributor.authorDemirci, Umut
dc.contributor.authorKaranlık, Hasan
dc.contributor.authorSoyder, Aykut
dc.contributor.authorDağ, Ahmet
dc.contributor.authorBilici, Ahmet
dc.contributor.authorDoğan, Mutlu
dc.contributor.authorKöksal, Hande
dc.contributor.authorŞendur, Mehmet Ali Nahit
dc.contributor.authorGülçelik, Mehmet Ali
dc.contributor.authorMaralcan, Göktürk
dc.contributor.authorCabıoğlu, Neslihan
dc.contributor.authorYeniay, Levent
dc.contributor.authorUtkan, Zafer
dc.contributor.authorŞimşek, Turgay
dc.contributor.authorKaradurmuş, Nuri
dc.contributor.authorDağlar, Gül
dc.contributor.authorYıldız, Birol
dc.contributor.authorUras, Cihan
dc.contributor.authorTükenmez, Mustafa
dc.contributor.authorYıldırım, Ahmet
dc.contributor.authorKutun, Suat
dc.contributor.authorÖzaslan, Cihangir
dc.contributor.authorKaraman, Niyazi
dc.contributor.authorAkçay, Müfide Nuran
dc.contributor.authorToktaş, Osman
dc.contributor.authorSezgin, Efe
dc.date.accessioned2021-10-21T08:50:00Z
dc.date.available2021-10-21T08:50:00Z
dc.date.issued2021en_US
dc.identifier.citationSoran, A., Doğan, L., Işık, A., Özbaş, S., Can Trabulus, D., Demirci, U. ... Sezgin, E. (2021). The effect of primary surgery in patients with de novo stage IV breast cancer with bone metastasis only (Protocol BOMET MF 14-01): A multi-center, prospective registry study. Annals of Surgical Oncology, 28(9), 5048-5057. https://dx.doi.org/10.1245/s10434-021-09621-8en_US
dc.identifier.issn1068-9265
dc.identifier.issn1534-4681
dc.identifier.urihttps://dx.doi.org/10.1245/s10434-021-09621-8
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8493
dc.description.abstractBackground More evidence shows that primary surgery for de novo metastatic breast cancer (BC) prolongs overall survival (OS) in selected cases. The aim of this study was to evaluate the role of locoregional treatment (LRT) in BC patients with de novo stage IV bone only metastasis (BOM). Methods The prospective, multicenter registry study BOMET MF14-01 was initiated in May 2014. Patients with de novo stage IV BOM BC were divided into two groups: those receiving systemic treatment (ST group) and those receiving LRT (LRT group). Patients who received LRT were further divided into two groups: ST after LRT (LRT + ST group) and ST before LRT (ST + LRT group). Results We included 505 patients in this study; 240 (47.5%) patients in the ST group and 265 (52.5%) in the LRT group. One hundred and thirteen patients (26.3%) died in the 34-month median follow-up, 85 (35.4%) in the ST group and 28 (10.5%) in LRT group. Local progression was observed in 39 (16.2%) of the patients in the ST group and 18 (6.7%) in the LRT group (p = 0.001). Hazard of death was 60% lower in the LRT group compared with the ST group (HR 0.40, 95% CI 0.30-0.54, p < 0.0001). Conclusion In this prospectively maintained registry study, we found that LRT prolonged survival and decreased locoregional recurrence in the median 3-year follow-up. Timing of primary breast surgery either at diagnosis or after ST provided a survival benefit similar to ST alone in de novo stage IV BOM BC patients.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectProtocol BOMET MF 14-01en_US
dc.subjectBone Metastasisen_US
dc.subjectPrimary Surgeryen_US
dc.titleThe effect of primary surgery in patients with de novo stage IV breast cancer with bone metastasis only (Protocol BOMET MF 14-01): A multi-center, prospective registry studyen_US
dc.typearticleen_US
dc.relation.ispartofAnnals of Surgical Oncologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.identifier.volume28en_US
dc.identifier.issue9en_US
dc.identifier.startpage5048en_US
dc.identifier.endpage5057en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1245/s10434-021-09621-8en_US
dc.identifier.wosqualityQ1en_US
dc.identifier.scopusqualityQ1en_US


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