The effect of gender on disease activity and clinical characteristics in patients with axial psoriatic arthritis
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2021Author
Nas, KemalKılıç, Erkan
Tekeoğlu, İbrahim
Keskin, Yaşar
Çevik, Remzi
Sargın, Betül
Acer Kasman, Sevtap
Alkan, Hakan
Şahin, Nilay
Cengiz, Gizem
Cüzdan, Nihan
Albayrak Gezer, İlknur
Keskin, Dilek
Mülkoğlu, Cevriye
Reşorlu, Hatice
Ataman, Şebnem
Bal, Ajda
Baykul, Merve
Duruöz, Mehmet Tuncay
Küçükakkaş, Okan
Yurdakul, Ozan Volkan
Alkan Melikoğlu, Meltem
Ayhan, Fikriye Figen
Bodur, Hatice
Çalış, Mustafa
Çapkın, Erhan
Devrimsel, Gül
Gök, Kevser
Hizmetli, Sami
Kamanlı, Ayhan
Kocabaş, Hilal
Kutluk, Öznur
Şen, Nesrin
Şendur, Ömer Faruk
Toprak, Murat
Tolu, Sena
Tuncer, Tiraje
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Nas, K., Kılıç, E., Tekeoğlu, İ., Keskin, Y., Çevik, R., Sargın, B. ... Tuncer, T. (2021). The effect of gender on disease activity and clinical characteristics in patients with axial psoriatic arthritis. Modern Rheumatology, 31(4), 869-874. https://dx.doi.org/10.1080/14397595.2020.1812870Abstract
Objectives In this study, we aimed to evaluate the effect of gender on clinical findings, disease activity, functional status and quality of life in patients with axial involvement in Turkey. Methods Patients with PsA who met the CASPAR classification criteria were enrolled consequently in this cohort. Turkish League Against Rheumatism (TLAR)-Network was formed with the participation of 25 centres. The demographic variables, fatigue, diagnostic delay, the beginning of peripheral arthritis, enthesitis, dactylitis and spine involvement, inflammatory low back pain, BASFI, HAQ, HAQ-s, visual analogue scale-pain (VAS-pain), anxiety, depression and disease activity parameters (ESR, DAS28, BASDAI) were recorded. Axial involvement was assessed according to clinical and radiological data according to modified New York (MNYC) or Assessment of SpondyloArthritis international Society (ASAS) criteria. Results A total of 1018 patients with PsA were included in this study. Of the 373 patients with axial involvement, 150 were male (40.2%) and 223 (59.8%) were female. Spondylitis was detected in 14,7% of men and 21,9% of women in all patients. Pain score (VAS) (p < .002), fatigue (p < .001), ESR (p < .001), DAS28 (p < .001), BASDAI score (p < .001), PsAQoL (p < .001), HAQ score (p < ,01), HAQ-S score (p < .001), anxiety (p < .001), depression (p < .024), FACIT (p < .001) and FiRST (p < .001) scores were statistically significantly worse in women than males with axial PsA. However, quality of life was better (p < .001) and PASI score (p < .005) were statistically worse in male patients than in female patients with axial involvement. Conclusion This study has shown that the burden of disease in axial PsA has significant difference between genders. Disease activity, physical disability, functional limitation, depression and anxiety scores were higher in female patients, while quality of life were better and PASI score were higher in male patients. Therefore, we suggest that new strategies should be developed for more effective treatment of axial PsA in female patients.