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dc.contributor.authorHacıoğlu, Ayşa
dc.contributor.authorGündoğdu, Aycan
dc.contributor.authorNalbantoğlu, Ufuk
dc.contributor.authorKaraca, Züleyha
dc.contributor.authorUrhan, Muhammed Emre
dc.contributor.authorŞahin, Serdar
dc.contributor.authorDökmetaş, Hatice Sebile
dc.contributor.authorKadıoğlu, Pınar
dc.contributor.authorKeleştimur, Fahrettin
dc.date.accessioned2021-10-12T11:44:05Z
dc.date.available2021-10-12T11:44:05Z
dc.date.issued2021en_US
dc.identifier.citationHacıoğlu, A., Gündoğdu, A., Nalbantoğlu, U., Karaca, Z., Urhan, M. E., Şahin, S. ... Keleştimur, F. (2021). Gut microbiota in patients with newly diagnosed acromegaly: A pilot cross-sectional study. Pituitary, 24(4), 600-610. https://dx.doi.org/10.1007/s11102-021-01137-4en_US
dc.identifier.issn1386-341X
dc.identifier.issn1573-7403
dc.identifier.urihttps://dx.doi.org/10.1007/s11102-021-01137-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8437
dc.description.abstractPurpose Microbiota has crucial biological importance for human well-being. Bidirectional interaction exists between microbiota and the host, and there have been no studies investigating this interaction in patients with acromegaly. We aimed to analyze the composition of microbiota in patients with newly diagnosed acromegaly. Method Stool samples were obtained from the patients with newly diagnosed acromegaly in the Endocrinology Clinic of Erciyes University Medical School. The composition of microbiota was analyzed, and the results were compared to healthy volunteers matched to the patients in terms of age, gender and body mass index. Results Seven patients (three male, four female) with a mean age of 48 +/- 17.6 years were included in the study. The stool analysis revealed a significantly lower bacterial diversity in the patients with acromegaly. Bacteroidetes phylum was predominating in the patient group, and Firmicutes/Bacteroidetes ratio was altered significantly. Bifidobacterium, Collinsella, Bacteroides, Butyricimonas, Clostridium, Oscillospira, and Dialister were predominating in the control group. Conclusion The gut microbiota is significantly altered in patients with newly diagnosed acromegaly. Further prospective studies are needed to elucidate the causative relationship between acromegaly, colorectal pathologies, and microbial alterations.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAcromegalyen_US
dc.subjectBacteroidesen_US
dc.subjectGrowth Hormoneen_US
dc.subjectGut Microbiotaen_US
dc.subjectInsulin Like Growth Factor-1en_US
dc.subjectPituitaryen_US
dc.titleGut microbiota in patients with newly diagnosed acromegaly: A pilot cross-sectional studyen_US
dc.typearticleen_US
dc.relation.ispartofPituitaryen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.identifier.volume24en_US
dc.identifier.issue4en_US
dc.identifier.startpage600en_US
dc.identifier.endpage610en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s11102-021-01137-4en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ2en_US


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