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dc.contributor.authorBalcı, Nur
dc.contributor.authorKurgan, Şivge
dc.contributor.authorÇekici, Ali
dc.contributor.authorÇakır, Tülin
dc.contributor.authorSerdar, Muhittin Abdulkadir
dc.date.accessioned2021-10-12T09:56:26Z
dc.date.available2021-10-12T09:56:26Z
dc.date.issued2021en_US
dc.identifier.citationBalcı, N., Kurgan, Ş., Çekici, A., Çakır, T. ve Serdar, M. A. (2021). Free amino acid composition of saliva in patients with healthy periodontium and periodontitis. Clinical Oral Investigations, 25(6), 4175-4183. https://dx.doi.org/10.1007/s00784-021-03977-7en_US
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.urihttps://dx.doi.org/10.1007/s00784-021-03977-7
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8435
dc.description.abstractObjectives To identify and compare the free amino acids in the saliva of periodontitis patients and healthy individuals and to assess their levels in different periodontal disease types. Materials and methods There were three groups: healthy individuals (control (C); n = 20), Stage III Grade B generalized periodontitis (GP-B; n = 20), and Stage III Grade C generalized periodontitis (GP-C; n = 20). Clinical periodontal parameters were measured. Amino acid analysis of the saliva was accomplished by liquid chromatography-mass spectrometry (LC MS/MS), taking the mean concentration. Results Citrulline and carnosine concentrations were significantly higher in patients with periodontitis than in the control group (p < 0.017). Methionine, glutamic acid, and arginine showed significantly higher concentrations in GP-C, whereas proline and tryptophan showed higher concentrations in the GP-B group (p < 0.017). There was a significant correlation between methionine, citrulline, arginine, and carnosine and clinical periodontal parameters. Conclusions Our results demonstrate that periodontal status and disease type can result in variations in salivary amino acid (AA) content in correlation with clinical inflammatory signs. The significant correlation of methionine, citrulline, carnosine, and arginine with clinical parameters, regardless of systemic status, suggests that the levels of different salivary free AAs play roles in periodontitis.en_US
dc.language.isoengen_US
dc.publisherSpringer Heidelbergen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectFree Amino Acidsen_US
dc.subjectSalivaen_US
dc.subjectPeriodontitisen_US
dc.titleFree amino acid composition of saliva in patients with healthy periodontium and periodontitisen_US
dc.typearticleen_US
dc.relation.journalClinical Oral Investigationsen_US
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-7986-7085en_US
dc.identifier.volume25en_US
dc.identifier.issue6en_US
dc.identifier.startpage4175en_US
dc.identifier.endpage4183en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s00784-021-03977-7en_US


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