Clinical and demographic features of hidradenitis suppurativa: A multicentre study of 1221 patients with an analysis of risk factors associated with disease severity
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Erişim
info:eu-repo/semantics/embargoedAccessTarih
2021Yazar
Özkur, EzgiKaradağ, Ayşe Serap
Üstüner, P.
Aksoy, Bülent
Esme, Pelin
Çalışkan, E.
Akoğlu, Gülşen
Kalkan, Gülhan
Demirseren, Duriye Deniz
Polat, Mualla
Özden, Müge Güler
Kılınç, Fadime
Yalçınkaya İyidal, Ayşegül
Kıvanç Altunay, İlknur
Türkmen, Meltem
Uğurer, Ece
Baysak, Sevim
Fettahlıoğlu Karaman, Bilge
Mammadli, Kifayat
Baykal Selçuk, Leyla
Türkoğlu, Zülal
Atçı, Tolgahan
Didar Balcı, Didem
Özsoy Adışen, Esra
Temel, Berkay
Aktan, Serhat
Gelincik Kaçar, Nida
Gündüz, Kamer
Türel Ermertcan, Aylin
Özdemir, Mustafa
Ünal Çakıter, Alkım
Çölgeçen, Emine
Uçmak, Derya
Kelekçi, Handan Kıymet
Ataseven, Arzu
Durmaz, Koray
Kaya Özden, Hatice
Engin, Berat
Özbek Yazıcı, Sercan
Alpsoy, Erkan
Üst veri
Tüm öğe kaydını gösterKünye
Özkur, E., Karadağ, A. S., Üstüner, P., Aksoy, B., Esme, P., Çalışkan, E. ... Alpsoy, E. (2021). Clinical and demographic features of hidradenitis suppurativa: A multicentre study of 1221 patients with an analysis of risk factors associated with disease severity. Clinical and Experimental Dermatology, 46(3), 532-540. https://dx.doi.org/10.1111/ced.14478Özet
Background Hidradenitis suppurativa (HS) is a chronic, relapsing and debilitating inflammatory disease associated with profound morbidity.
Aim In this multicentre study, we investigated the demographic and clinical features of HS, and determined risk factors of disease severity.
Methods In total, 1221 patients diagnosed with HS from 29 centres were enrolled, and the medical records of each patient were reviewed.
Results The mean age of disease onset was 26.2 +/- 10.4 years, and almost 70% (n = 849) of patients were current or former smokers. Mean disease duration was 8.9 +/- 8.4 years with a delay in diagnosis of 5.8 +/- 3.91 years. Just over a fifth (21%; n = 256) of patients had a family history of HS. The axillary, genital and neck regions were more frequently affected in men than in women, and the inframammary region was more frequently affected in women than in men (P < 0.05 for all). Acne (40.8%), pilonidal sinus (23.6%) and diabetes mellitus (12.6%) were the most prevalent associated diseases. Of the various therapies used, antibiotics (76.4%) were most common followed by retinoids (41.7%), surgical interventions (32.0%) and biologic agents (15.4%). Logistic regression analysis revealed that the most important determinants of disease severity were male sex (OR = 2.21) and involvement of the genitals (OR = 3.39) and inguinal region (OR = 2.25). More severe disease was associated with comorbidity, longer disease duration, longer diagnosis delay and a higher number of smoking pack-years.
Conclusions Our nationwide cohort study found demographic and clinical variation in HS, which may help broaden the understanding of HS and factors associated with disease severity.
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Clinical and Experimental DermatologyCilt
46Sayı
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