Resting state alpha electroencephalographic rhythms are differently related to aging in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment

Erişim
info:eu-repo/semantics/closedAccessTarih
2021Yazar
Babiloni, ClaudioFerri, Raffaele
Noce, Giuseppe
Lizio, Roberta
Lopez, Susanna
Lorenzo, Ivan
Tucci, Federico
Soricelli, Andrea
Nobili, Flavio
Arnaldi, Dario
Fama, Francesco
Orzi, Francesco
Buttinelli, Carla
Giubilei, Franco
Cipollini, Virginia
Marizzoni, Moira
Güntekin, Bahar
Aktürk, Tuba
Hanoğlu, Lütfü
Yener, Görsev
Özbek, Yağmur
Stocchi, Fabrizio
Vacca, Laura
Frisoni, Giovanni B.
del Percio, Claudio
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Babiloni, C., Ferri, R., Noce, G., Lizio, R., Lopez, S., Lorenzo, I. ... del Percio, C. (2021). Resting state alpha electroencephalographic rhythms are differently related to aging in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment. Journal of Alzheimer's Disease, 82(3), 1085-1114. https://dx.doi.org/10.3233/JAD-201271Özet
Background: In relaxed adults, staying in quiet wakefulness at eyes closed is related to the so-called resting state electroencephalographic (rsEEG) rhythms, showing the highest amplitude in posterior areas at alpha frequencies (8-13 Hz). Objective: Here we tested the hypothesis that age may affect rsEEG alpha (8-12 Hz) rhythms recorded in normal elderly (Nold) seniors and patients with mild cognitive impairment due to Alzheimer's disease (ADMCI). Methods: Clinical and rsEEG datasets in 63 ADMCI and 60 Nold individuals (matched for demography, education, and gender) were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands, as well as fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into three subgroups based on age ranges (i.e., tertiles). Results: As compared to the younger Nold subgroups, the older one showed greater reductions in the rsEEG alpha rhythms with major topographical effects in posterior regions. On the contrary, in relation to the younger ADMCI subgroups, the older one displayed a lesser reduction in those rhythms. Notably, the ADMCI subgroups pointed to similar cerebrospinal fluid AD diagnostic biomarkers, gray and white matter brain lesions revealed by neuroimaging, and clinical and neuropsychological scores. Conclusion: The present results suggest that age may represent a deranging factor for dominant rsEEG alpha rhythms in Nold seniors, while rsEEG alpha rhythms in ADMCI patients may be more affected by the disease variants related to earlier versus later onset of the AD.
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Journal of Alzheimer's DiseaseCilt
82Sayı
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