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dc.contributor.authorYoldaş İlktaç, Havvanur
dc.contributor.authorKızıltan, Gül
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorÖzmen Toğay, Sine
dc.contributor.authorKeskin, İlknur
dc.contributor.authorÖzdemir, Ekrem Musa
dc.contributor.authorGünal, Mehmet Yalçın
dc.date.accessioned2021-08-19T06:13:36Z
dc.date.available2021-08-19T06:13:36Z
dc.date.issued2021en_US
dc.identifier.citationYoldaş İlktaç, H., Kızıltan, G., Ozansoy, M., Kılıç, Ü., Özmen Toğay, S., Keskin, İ. ... Günal, M. Y. (2021). The effect of probiotic and omega-3 supplements on total oxidant and total antioxidant levels in experimental colitis. Clinical and Experimental Health Sciences, 11(2), 362-366. https://dx.doi.org/10.33808/clinexphealthsci.865058en_US
dc.identifier.issn2459-1459
dc.identifier.urihttps://dx.doi.org/10.33808/clinexphealthsci.865058
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7869
dc.description.abstractObjective: Treatment of inflammatory bowel disease (IBD) usually involves medical therapy. For this reason, it is recommended to seek alternative treatment methods such as nutritional therapy. The aim of the study is to evaluate the effects of probiotics and omega-3 fatty acids on total oxidant and total antioxidant levels in an experimental colitis model. Methods: Mice were randomly divided into five groups (n= 10/group) as healthy group, colitis group, group treated with probiotics (VSL#3), group treated with omega-3 (w-3), and group treated with both probiotics and omega-3. To induce experimental colitis, 200 mg/kg dinitrobenzene sulfonic acid (DNBS) + 30% ethanol combination was rectally administered to anesthetized mice. Total oxidant (TOS) and total antioxidant (TAS) levels were measured at the tissue level. Results: Lower concentrations of TOS were observed in the probiotics groups (2.11 +/- 0.23 mmol H2O2 Eq/L), probiotics+omega-3 (2.56 +/- 1.18 mmol H2O2 Eq/L), and omega-3 (3.02 +/- 1.88 mmol H2O2 Eq/L) groups compared to the colitis group (3.11 +/- 0.91 mmol H2O2 Eq/L) (p>0.05). Higher TOS and TAS level were observed in the control colitis group compared to other groups; however, the differences were not statistically significant. Conclusion: Our findings showed that TAS and TOS levels were positively affected by the use of probiotic supplements in IBD. It was determined that using w-3 alone was ineffective in decreasing TOS levels. Studies with higher dosages and longer treatment periods are needed to better observe the effects of nutritional supplements on TOS and TAS parameters in inflammatory bowel diseases.en_US
dc.language.isoengen_US
dc.publisherMarmara Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProbioticsen_US
dc.subjectOmega-3 Fatty Acidsen_US
dc.subjectTotal Antioxidant Levelen_US
dc.subjectTotal Oxidant Levelen_US
dc.subjectColitisen_US
dc.subjectInflammatory Bowel Diseasesen_US
dc.titleThe effect of probiotic and omega-3 supplements on total oxidant and total antioxidant levels in experimental colitisen_US
dc.typearticleen_US
dc.relation.journalClinical and Experimental Health Sciencesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-7059-1884en_US
dc.authorid0000-0001-9416-7757en_US
dc.identifier.volume11en_US
dc.identifier.issue2en_US
dc.identifier.startpage362en_US
dc.identifier.endpage366en_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/115S679
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.33808/clinexphealthsci.865058en_US


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