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dc.contributor.authorKarakaş, Nihal
dc.contributor.authorKılıç, Ülkan
dc.date.accessioned2021-08-02T10:01:26Z
dc.date.available2021-08-02T10:01:26Z
dc.date.issued2021en_US
dc.identifier.citationKarakaş, N. ve Kılıç, Ü. (2021). Integrin α5β1 mediated cellular reorganization in human mesenchymal stem cells during neuronal differentiation. In Vivo, 35(4), 2127-2134. https://dx.doi.org/10.21873/invivo.12482en_US
dc.identifier.issn0258-851X
dc.identifier.issn1791-7549
dc.identifier.urihttps://dx.doi.org/10.21873/invivo.12482
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7645
dc.description.abstractBackground/Aim: Mesenchymal stem cells (MSCs) have been widely used for yielding neurons in culture to study nervous system pathologies and develop regenerative approaches. In this study, cellular rearrangements of human MSCs related to the expression of the fibronectin common receptor integrin alpha 5 beta 1 and its cell surface localization during neuronal differentiation, were examined. Materials and Methods: Proliferation kinetics of neuronal induced hMSCs (hMd-Neurons) were quantified by BrdU assay, and hMd-Neurons were immunostained for neuronal marker expression. Additionally, cDNA and protein samples were collected at different time points for integrin alpha 5 beta 1 expression analysis. Results: Endogenous integrin alpha 5 beta 1 expression was significantly upregulated by day 6 and maintained until day 12. Cell surface localization of alpha 5 beta 1 integrin was increased by day 6; the integrin was internalized into the cytosol by day 12. Conclusion: Integrin dynamics around day 6 of differentiation might be involved in neuronal differentiation and maturation or specification of hMd-Neurons.en_US
dc.description.sponsorshipIstanbul Medipol University, Scientific Research Projects Committee (BAP)en_US
dc.language.isoengen_US
dc.publisherInternational Institute of Anticancer Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntegrinen_US
dc.subjectIntegrin α5β1en_US
dc.subjectMesenchymal Stem Cellsen_US
dc.subjectNeuronal Differentiationen_US
dc.titleIntegrin α5β1 mediated cellular reorganization in human mesenchymal stem cells during neuronal differentiationen_US
dc.title.alternativeIntegrin alpha 5 beta 1 mediated cellular reorganization in human mesenchymal stem cells during neuronal differentiationen_US
dc.typearticleen_US
dc.relation.ispartofIn Vivoen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsüen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-9096-1512en_US
dc.authorid0000-0002-6895-8560en_US
dc.identifier.volume35en_US
dc.identifier.issue4en_US
dc.identifier.startpage2127en_US
dc.identifier.endpage2134en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.21873/invivo.12482en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ2en_US


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