Show simple item record

dc.contributor.authorHelvacıoğlu, Didem
dc.contributor.authorDemircioğlu Turan, Serap
dc.contributor.authorGüran, Tülay
dc.contributor.authorAtay, Zeynep
dc.contributor.authorDağçınar, Adnan
dc.contributor.authorBezen, Diğdem
dc.contributor.authorKarakılıç Özturan, Esin
dc.contributor.authorDarendeliler, Feyza
dc.contributor.authorYüksel, Ayşegül
dc.contributor.authorDursun, Fatma
dc.contributor.authorKılınç, Suna
dc.contributor.authorSemiz, Serap
dc.contributor.authorAbalı, Saygın
dc.contributor.authorYıldız, Metin
dc.contributor.authorÖnder, Aşan
dc.contributor.authorBereket, Abdullah
dc.identifier.citationHelvacıoğlu, D., Demircioğlu Turan, S., Güran, T., Atay, Z., Dağçınar, A., Bezen, D., ... Bereket, A. (2021). Cranial MRI abnormalities and long-term follow-up of the lesions in 770 girls with central precocious puberty. The Journal of Clinical Endocrinology & Metabolism, 106(7), e2557-e2566.
dc.description.abstractCONTEXT: Central precocious puberty (CPP) may arise from central nervous system (CNS) lesions in a few affected girls. Recently, the incidence of girls with CPP has increased mostly in 6-8 year olds, in whom the necessity of magnetic resonance imaging (MRI) is debated. OBJECTIVE: To investigate the frequency, long-term outcome and potential predictors of CNS lesions in a large cohort of girls with CPP. METHODS: A multicenter cohort of 770 Turkish girls with CPP who had systematic cranial MRI between 2005 and 2017. Age at puberty onset was <6 years in 116 and 6-8 years in 654. CNS lesions were followed until final decision(6.2 ± 3.1 years). Potential predictors of CNS lesions were evaluated by univariate analyses. RESULTS: A total of 104/770 (13.5%) girls had abnormal brain MRI. Of these, 2.8% were previously known CNS lesions, 3.8% had newly detected and causally related CNS lesions, 3.1 % were possibly, related and 3.8% were incidental. Only 2 (0.25%) neoplastic lesions (1 low grade glioma and 1 meningioma) were identified; neither required intervention over follow-up of 6 and 3.5 years respectively. Age at breast development <6 years (odds ratio [OR] 2.38; 95% CI 1.08-5.21) and the peak luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio >0.6 (OR 3.13; 95% CI 1.02-9.68) were significantly associated with CNS lesions. However, both patients with neoplastic lesions were >6 years old. CONCLUSION: Although age and LH/FSH ratio are significant predictors of CNS lesions, their predictive power is weak. Thus, systematic MRI seems to be the most efficient current approach to avoid missing an occult CNS lesion in girls with CPP, despite the low likelihood of finding a lesion requiring intervention.en_US
dc.publisherNLM (Medline)en_US
dc.subjectCNS Imagingen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectPrecocious Pubertyen_US
dc.titleCranial MRI abnormalities and long-term follow-up of the lesions in 770 girls with central precocious pubertyen_US
dc.relation.ispartofThe Journal of Clinical Endocrinology & Metabolismen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record