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Current status of mucoadhesive gel systems for buccal drug delivery

Access

info:eu-repo/semantics/closedAccess

Date

2021

Author

Üstündağ Okur, Neslihan
Özcan Bülbül, Ece
Yağcılar, Ayşe Pınar
Siafaka, Panoraia I

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Citation

Üstündağ Okur, N., Özcan Bülbül, E., Yağcılar, A. P. ve Siafaka, P. I. (2021). Current status of mucoadhesive gel systems for buccal drug delivery. Current Pharmaceutical Design, 27(17), 2015-2025. https://dx.doi.org/10.2174/1381612824666210316101528

Abstract

Background: Buccal drug delivery is a fascinating research field. Gel-based formulations present potent characteristics as buccal systems since they have great physicochemical properties. Methods: Among the various gels, in situ gels are viscous colloidal systems consisting of polymers; when physiological conditions change (pH, temperature, ion activation), they are transformed into the gel phase. These systems can improve bioavailability. Other systems, such as nanogels or emulgels can also be applied for buccal delivery with promising results. Polymeric gel-based systems can be produced by natural, semisynthetic, and synthetic polymers. Their main advantage is that the active molecules can be released in a sustained and controllable manner. Several gels based on chitosan are produced for the entrapment of drugs demonstrating efficient retention time and bioavailability due to chitosan mucoadhesion. Besides polysaccharides, poloxamers and carbopol are also used in buccal gels due to their high swelling ability and reversed thermal gelation behavior. Results: Herein, the authors focused on the current development of mucoadhesive gel systems used in buccal drug delivery. After explaining buccal drug delivery and mucoadhesion, various studies with hydrogels, in situ gels, and nanogels were analyzed as buccal gel systems. Various mucoadhesive gel studies with mucoadhesive polymers have been studied and summarized. This review is presented as valuable guidance to scientists in formulating buccal mucoadhesive drug delivery systems. Conclusion: This review aimed to assist researchers working on buccal drug delivery by summarizing buccal drug delivery, mucoadhesion, and buccal mucoadhesive gel systems recently found in the literature.

WoS Q Kategorisi

Q3

xmlui.dri2xhtml.METS-1.0.item-scopusquality

Q2

Source

Current Pharmaceutical Design

Volume

27

Issue

17

URI

https://dx.doi.org/10.2174/1381612824666210316101528
https://hdl.handle.net/20.500.12511/7300

Collections

  • Diğer Yayınlar Koleksiyonu [13]
  • PubMed İndeksli Yayınlar Koleksiyonu [3772]
  • Scopus İndeksli Yayınlar Koleksiyonu [5815]
  • WoS İndeksli Yayınlar Koleksiyonu [5982]



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