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dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorŞakul, Ayşe Arzu
dc.date.accessioned2021-06-10T07:52:40Z
dc.date.available2021-06-10T07:52:40Z
dc.date.issued2021en_US
dc.identifier.citationOkur, M. E. ve Şakul, A. A. (2021). Mechanism of antinociceptive action of syringic acid. Journal of Research in Pharmacy, 25(3), 277-286. https://dx.doi.org/10.29228/jrp.18en_US
dc.identifier.issn2630-6344
dc.identifier.urihttps://dx.doi.org/10.29228/jrp.18
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7121
dc.description.abstractSyringic acid presents various biological properties such as antioxidant, anti-inflammatory, anticancer, and other activities. The present experiment aimed to investigate the effect of the oral administration of syringic acid (10, 50, and 100 mg/kg) on its possible nociceptive response using hot-plate and tail-flick assay in the Balb-C mice model. The mice were pre-treated with 5 mg/kg atropine 15 min before, 1mg/kg mecamylamine 20 min before, 1mg/kg ketanserin 30 min before, 1 mg/kg ondansetron 30 min before, 1mg/kg yohimbine 30 min before, 1 mg/kg prazosin 30 min before and 5 mg/kg naloxone 15min before the administration of the Syringic acid. Dose-dependent antinociceptive activity of syringic acid was reported for 50 and 100 mg/kg doses in tail-flick and hot-plate assays, respectively. In further, mecamylamine, yohimbine, and naloxone significantly reversed syringic acid-induced response to thermal stimuli in tail-flick and hot-plate assays, respectively. From the data, it was confirmed that syringic acid presents central antinociceptive effects which may be coordinated by supraspinal/spinal mediated cholinergic, opioidergic, and adrenergic, inflection.en_US
dc.language.isoengen_US
dc.publisherMarmara Universityen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntinociceptionen_US
dc.subjectMuscarinic Receptorsen_US
dc.subjectOpioidergic Receptorsen_US
dc.subjectAlpha(2)-Adrenoceptorsen_US
dc.subjectSyringic Aciden_US
dc.titleMechanism of antinociceptive action of syringic aciden_US
dc.typearticleen_US
dc.relation.journalJournal of Research in Pharmacyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalıen_US
dc.identifier.volume25en_US
dc.identifier.issue3en_US
dc.identifier.startpage277en_US
dc.identifier.endpage286en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.29228/jrp.18en_US


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