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dc.contributor.authorArıcı Düz, Özge
dc.contributor.authorOlmuşçelik, Oktay
dc.contributor.authorGemici, Aliihsan
dc.contributor.authorSaatçi Sancaktepe, Özlem
dc.date.accessioned2021-05-21T10:35:53Z
dc.date.available2021-05-21T10:35:53Z
dc.date.issued2021en_US
dc.identifier.citationArıcı Düz, Ö., Olmuşçelik, O., Gemici, A. ve Saatçi Sancaktepe, Ö. (2021). Evaluation of pai-1 polymorphisms in central and peripheral thromboembolies. Journal of Experimental and Clinical Medicine (Turkey), 38(2), 167-171. https://dx.doi.org/10.52142/omujecm.38.2.20en_US
dc.identifier.issn1309-4483
dc.identifier.urihttps://dx.doi.org/10.52142/omujecm.38.2.20
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6878
dc.description.abstractThromboembolism is a clinical finding that occurs due to thrombus; formed in the vascular system and has various etiological factors. It can be classified as central and peripheral thromboembolism. Our objective in this study is to explore genetic risk factors in central and peripheral thromboembolism and reveal the differences. 342 thromboembolism patients were retrospectively included to the study between January 2016 and December 2019. Demographic characteristics, risk factors for thromboembolism and genetic mutations in central and peripheral thromboembolism groups were overviewed. The genetic mutations evaluated in patients were Factor V Leiden G1691A, Factor V HR1299R, Factor II (Prothrombin) G20210A, MTHFR (Methylenetetrahydrofolate reductase) C677T, MTHFR A1298C, PAI 4G/5G. Within the scope of the study, genetic analyzes of 106 patients were reached and included in the study. Seventy-two central thromboembolism (69.8%), 34 (31.2%) peripheral thromboembolisms were detected. Sixty-three of the central thromboembolisms were from arterial and nine were from venous origin. There was no significant difference between age, gender and risk factors of central thromboembolism and peripheral thromboembolism patients (p0.05), but smoking was more common in central thromboembolism patients (p: 0.041). 4G/5G polymorphism was observed more frequently in patients with central thromboembolism (p: 0.039). Thromboembolism is a multifactorial disease, PAI-1 4G/5G polymorphism is a medium risk factor for thromboembolism. We conclude that PAI-1 4G/5G polymorphism is more frequent in central thromboembolism than peripheral thromboembolism and its evaluation can give more information about the thromboembolic risk analyze.en_US
dc.language.isoengen_US
dc.publisherOndokuz Mayıs Üniversitesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStrokeen_US
dc.subjectPaien_US
dc.subjectThromboembolismen_US
dc.subjectMutationsen_US
dc.titleEvaluation of pai-1 polymorphisms in central and peripheral thromboemboliesen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.authorid0000-0003-0334-811Xen_US
dc.authorid0000-0002-9815-1848en_US
dc.authorid0000-0002-3385-8359en_US
dc.identifier.volume38en_US
dc.identifier.issue2en_US
dc.identifier.startpage167en_US
dc.identifier.endpage171en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.52142/omujecm.38.2.20en_US
dc.identifier.scopusqualityQ4en_US


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