dc.contributor.author | Yılmaz, Gökhan | |
dc.contributor.author | Tanrıkulu, Yusuf | |
dc.date.accessioned | 2021-04-06T08:31:47Z | |
dc.date.available | 2021-04-06T08:31:47Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Yılmaz, G. ve Tanrıkulu, Y. (2021). Short-term results of platelet-rich plasma in the treatment of chronic anal fissure: Randomized controlled clinical study. Diseases of the Colon & Rectum, 64(6), 714-723. https://dx.doi.org/10.1097/DCR.0000000000001903 | en_US |
dc.identifier.issn | 0012-3706 | |
dc.identifier.issn | 1530-0358 | |
dc.identifier.uri | https://dx.doi.org/10.1097/DCR.0000000000001903 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/6701 | |
dc.description.abstract | Background: Anal fissure is one of the most common benign anal disorders, and medical treatments play an important role in its management.Objective: The purpose of this study was to investigate the short-term effects and success of platelet-rich-plasma in the treatment of chronic anal fissure.Design: The study is a two parallel-group, randomized, controlled clinical trial.Settings: The study was carried out in two tertiary university hospitals.Patients: Forty-four-patients with chronic anal fissure were randomly assigned to platelet-rich-plasma treatment or control group. Presenting symptoms and pain scores were recorded on enrolment. The control patient self-administered topical glyceryl trinitrate. Platelet-rich-plasma was injected locally in the intervention group followed by self-administered glyceryl trinitrate.Main outcome measures: Primary outcome measure is a reduction in pain scores.Results: On day 10 and one month after treatment, the mean pain score was significantly lower in the platelet-rich-plasma patients than in the controls (p=0.005 and p<0.005, respectively). By one month after treatment, mean pain score declined by 5.7 points in the platelet-rich plasma-treated group compared with a 4.1 mean pain score decline in the control group (mean difference:1.6 points [95% confidence interval;0.3-2.9]).According to the repeated-measures analyses, Pain scores decreased in both groups, but the decrease in the treatment group was statistically higher than the control group (p<0.001).Complete epithelialization and recovery rates were significantly higher in the platelet-rich-plasma group than in controls at all follow-up times, with p-values ranging from 0.034 to<0.001.The observed difference in complete epithelialization after two months of treatment between the platelet-rich-plasma group and the control group was 56.2% with a 95% confidence interval of 14.03% to 98.4%.Limitations: This study was limited by its small sample size and long-term follow-up of the patients was not given.Conclusions: Platelet-rich-plasma reduced complaints and accelerated epithelialization and healing in patients with chronic anal fissures. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Lippincott | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Botulinum Toxin | en_US |
dc.subject | Chronic Anal Fissure | en_US |
dc.subject | Lateral Internal Sphincterotomy | en_US |
dc.subject | Medical Treatment | en_US |
dc.subject | Platelet Rich Plasma | en_US |
dc.title | Short-term results of platelet-rich plasma in the treatment of chronic anal fissure: Randomized controlled clinical study | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Diseases of the Colon & Rectum | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-0889-9586 | en_US |
dc.identifier.volume | 64 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 714 | en_US |
dc.identifier.endpage | 723 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1097/DCR.0000000000001903 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |