DNA repair genes and chronic myeloid leukemia: ERCC2 (751), XRCC1 (399), XRCC4-Intron 3, XRCC4 (-1394) gene polymorphisms
Oğuz Savran, Fatma
Tomatır, Ayşe Gaye
MetadataShow full item record
CitationÖzdilli, K., Pehlivan, M., Serin, İ., Oğuz Savran, F., Tomatır, A. G. ve Pehlivan, S. (2021). DNA repair genes and chronic myeloid leukemia: ERCC2 (751), XRCC1 (399), XRCC4-Intron 3, XRCC4 (-1394) gene polymorphisms. Mediterranean Journal of Hematology and Infectious Diseases, 13. https://dx.doi.org/10.4084/MJHID.2021.020
To the editor. Chronic myeloid leukemia (CML), which is characterized by the overproduction of mature cells in the granulocytic series, is included in the group of chronic myeloproliferative neoplasms.1 It is the first disease ascertained as due to a specific chromosomal anomaly emerging from a reciprocal translocation between chromosomes 9 and 22. A chimeric gene denominated as the Philadelphia (Ph) chromosome is the product of the fusion of the Abelson oncogene (ABL) from chromosome 9q34 with the breakpoint cluster region (BCR) on chromosome 22q11.2, t (9;22)(q34;q11.2).