Abnormalities of resting state cortical EEG rhythms in subjects with mild cognitive impairment due to alzheimer's and lewy body diseases
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Erişim
info:eu-repo/semantics/closedAccessTarih
2018Yazar
Babiloni, Claudiodel Percio, Claudio
Lizio, Roberta
Noce, Giuseppe
Lopez, Susanna
Soricelli, Andrea
Ferri, Raffaele
Pascarelli, Maria Teresa
Catania, Valentina
Nobili, Flavio
Arnaldi, Dario
Fama, Francesco
Aarsland, Dag
Orzi, Francesco
Buttinelli, Carla
Giubilei, Franco
Onofrj, Marco
Stocchi, Fabrizio
Vacca, Laura
Stirpe, Paola
Fuhr, Peter
Gschwandtner, Ute
Ransmayr, Gerhard
Garn, Heinrich
Fraioli, Lucia
Pievani, Michela
Frisoni, Giovanni B.
D'Antonio, Fabrizia
de Lena, Carlo
Güntekin, Bahar
Hanoğlu, Lütfü
Başar, Erol
Yener, Görsev
Emek-Savaş, Derya Durusu
Triggiani, Antonio Ivano
Franciotti, Raffaella
Taylor, John Paul
de Pandis, Maria Francesca
Bonanni, Laura
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Babiloni, C., del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A. ... Bonanni, L. (2018). Abnormalities of resting state cortical EEG rhythms in subjects with mild cognitive impairment due to alzheimer's and lewy body diseases. Journal of Alzheimer's Disease, 62(1), 247-268. https://dx.doi.org/10.3233/JAD-170703Özet
The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC > 0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers.
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Journal of Alzheimer's DiseaseCilt
62Sayı
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