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dc.contributor.authorAydemir Sezer, Ümran
dc.contributor.authorÖztürk Yavuz, Kevser
dc.contributor.authorÖrs, Gizem
dc.contributor.authorBay, Sadık
dc.contributor.authorAru, Başak
dc.contributor.authorSöğüt, Oğuz
dc.contributor.authorAkgül Çağlar, Tuba
dc.contributor.authorBozkurt, Mehmet Recep
dc.contributor.authorÇağavi, Esra
dc.contributor.authorYanıkkaya Demirel, Gülderen
dc.contributor.authorSezer, Serdar
dc.contributor.authorKaraca, Hüseyin
dc.date.accessioned2021-01-11T08:32:51Z
dc.date.available2021-01-11T08:32:51Z
dc.date.issued2020en_US
dc.identifier.citationAydemir Sezer, Ü., Öztürk Yavuz, K., Örs, G., Bay, S., Aru, B., Söğüt, O. ... Karaca, H. (2020). Zero-valent iron nanoparticles containing nanofiber scaffolds for nerve tissue engineering. Journal of Tissue Engineering and Regenerative Medicine, 14(12), 1815-1826. https://dx.doi.org/10.1002/term.3137en_US
dc.identifier.issn1932-6254
dc.identifier.issn1932-7005
dc.identifier.urihttps://dx.doi.org/10.1002/term.3137
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6216
dc.description.abstractRegeneration of nerve tissue is a challenging issue in regenerative medicine. Especially, the peripheral nerve defects related to the accidents are one of the leading health problems. For large degeneration of peripheral nerve, nerve grafts are used in order to obtain a connection. These grafts should be biodegradable to prevent second surgical intervention. In order to make more effective nerve tissue engineering materials, nanotechnological improvements were used. Especially, the addition of electrically conductive and biocompatible metallic particles and carbon structures has essential roles in the stimulation of nerves. However, the metabolizing of these structures remains to wonder because of their nondegradable nature. In this study, biodegradable and conductive nerve tissue engineering materials containing zero-valent iron (Fe) nanoparticles were developed and investigated under in vitro conditions. By using electrospinning technique, fibrous mats composed of electrospun poly(epsilon-caprolactone) (PCL) nanofibers and Fe nanoparticles were obtained. Both electrical conductivity and mechanical properties increased compared with control group that does not contain nanoparticles. Conductivity of PCL/Fe5 and PCL/Fe10 increased to 0.0041 and 0.0152 from 0.0013 Scm(-1), respectively. Cytotoxicity results indicated toxicity for composite mat containing 20% Fe nanoparticles (PCL/Fe20). SH-SY5Y cells were grown on PCL/Fe10 best, which contains 10% Fe nanoparticles. Beta III tubulin staining of dorsal root ganglion neurons seeded on mats revealed higher cell number on PCL/Fe10. This study demonstrated the impact of zero-valent Fe nanoparticles on nerve regeneration. The results showed the efficacy of the conductive nanoparticles, and the amount in the composition has essential roles in the promotion of the neurites.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectElectrospinen_US
dc.subjectIron Nanoparticlesen_US
dc.subjectNerve Regenerationen_US
dc.subjectPolycaprolactoneen_US
dc.subjectTissue Engineeringen_US
dc.subjectZero Valenten_US
dc.titleZero-valent iron nanoparticles containing nanofiber scaffolds for nerve tissue engineeringen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Tissue Engineering and Regenerative Medicineen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsüen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Sinirbilim Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-8089-1330en_US
dc.authorid0000-0002-7199-583Xen_US
dc.identifier.volume14en_US
dc.identifier.issue12en_US
dc.identifier.startpage1815en_US
dc.identifier.endpage1826en_US
dc.relation.ecinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/214S672
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1002/term.3137en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ2en_US


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