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dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorYaşar Şirin, Duygu
dc.contributor.authorÖzbek, Hanefi
dc.date.accessioned2020-12-30T08:22:59Z
dc.date.available2020-12-30T08:22:59Z
dc.date.issued2020en_US
dc.identifier.citationYılmaz, İ., Karaarslan, N., Yaşar Şirin, D. ve Özbek, H. (2020). Pharmaco-molecular assessment of the effects of anandamide and its antagonists on hippocampal tissue in Wistar albino rats. European Review for Medical and Pharmacological Sciences, 24(22), 11871-11882. https://dx.doi.org/10.26355/eurrev_202011_23845en_US
dc.identifier.issn1128-3602
dc.identifier.urihttps://dx.doi.org/10.26355/eurrev_202011_23845
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6170
dc.description.abstractOBJECTIVE: The members of the matrix metalloproteinase (MMP) family and cannabinoids (CBs) are reportedly associated with hippocampus-dependent memory functions. However, the effects of endogenously formed CBs on hippocampal long-term potentiation remain unknown. The present study aimed to investigate the changes in the gene and protein expression levels of matrix metallopeptidase 9 (MMP-9), phosphatase and tensin homolog (PTEN), and NOTCH receptor 1 (NOTCH1) in rat hippocampal tissues treated with anandamide (AEA), AM251, 6-iodopravadolin (AM630), and N-[4-{[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl}phenyl] (ML193). MATERIALS AND METHODS: The subjects were divided into 10 groups (n = five per group). The pharmaceuticals were administered via intraperitoneal injection once a day for seven days, except for the control group. The resected hippocampal tissues were then evaluated using a quantitative real-time polymerase chain reaction (RT-qPCR) and Western blot analysis. The data obtained were statistically analyzed, and p < 0.01 was considered statistically significant. RESULTS: Contrary to the literature, the changes in MMP-9 expression were not statistically significant, but the changes in PTEN and NOTCH1 were. The findings of this in vivo experimental study revealed that the agonists and antagonists acting on the CB system have significant molecular effects on hippocampal tissue. CONCLUSIONS: The changes in gene and protein expressions may be one of the reasons for the neurodegenerative processes observed in patients using these agonists and antagonists, whose effects on the CB system have not been fully explained yet. Our study can contribute to the literature as it is the first study investigating the MMP-9, PTEN and NOTCH1 gene and protein expression.en_US
dc.description.sponsorshipMedical Research Center laboratory (Istanbul Medipol University)en_US
dc.language.isoengen_US
dc.publisherVerduci Editore s.r.len_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnandamideen_US
dc.subjectHippocampusen_US
dc.subjectMMP-9en_US
dc.subjectNOTCH1en_US
dc.subjectPTENen_US
dc.titlePharmaco-molecular assessment of the effects of anandamide and its antagonists on hippocampal tissue in Wistar albino ratsen_US
dc.typearticleen_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-2003-6337en_US
dc.authorid0000-0002-8084-7855en_US
dc.identifier.volume24en_US
dc.identifier.issue22en_US
dc.identifier.startpage11871en_US
dc.identifier.endpage11882en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.26355/eurrev_202011_23845en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ2en_US


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