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dc.contributor.authorBektaş, Gonca
dc.contributor.authorÖnal, Hasan
dc.contributor.authorAdal, Erdal
dc.date.accessioned2020-12-01T08:38:04Z
dc.date.available2020-12-01T08:38:04Z
dc.date.issued2020en_US
dc.identifier.citationBektaş, G., Önal, H. ve Adal, E. (2020). The factors relevant to partial remission in children with type 1 diabetes mellitus after measles vaccination: A retrospective study. Journal of Medical Virology, 92(12), 2955-2960. https://dx.doi.org/10.1002/jmv.25734en_US
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.urihttps://dx.doi.org/10.1002/jmv.25734
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6067
dc.description.abstractWe aimed to identify the determinants of partial remission in patients with type 1 diabetes mellitus (DM), and whether there is an influence of vaccination against measles on partial remission. This was a retrospective study consisting of consecutive patients diagnosed with type 1 DM followed-up from 1 September 2010, through 30 November 2011. The study included children vaccinated within 3 months after diagnosis, and children unvaccinated during the first 12 months of the disease. The daily insulin dose, hemoglobin A1c, and C-peptide levels, and whether children are in partial remission based on the insulin dose-adjusted HbA1c were recorded at diagnosis and 3, 6, 9, 12, 24, and 36 months. A total of 55 children with type 1 DM were analyzed. Thirty-one patients (56.4%) reached partial remission during the follow-up period, whereas 24 of them did not. Patients with diabetic ketoacidosis (DKA) at diagnosis were less likely to reach partial remission than patients without DKA (odds ratio [OR], 0.24; 95% confidence interval [CI], 0.062-0.946;P = .038). Patients vaccinated against measles were more likely to be in partial remission than patients unvaccinated (OR, 4.2; 95% CI, 1.35-13;P = .011). Partial remission was significantly associated with the C-peptide level and insulin dosage at diagnosisP = .002;P = .013, respectively). The lack of DKA, higher C-peptide level, and lower insulin dosage at diagnosis, and vaccination against measles after diagnosis may have an influence on partial clinical remission in patients with new-onset type 1 DM.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectImmune Systemen_US
dc.subjectImmunomodulationen_US
dc.subjectMeasles Virusen_US
dc.titleThe factors relevant to partial remission in children with type 1 diabetes mellitus after measles vaccination: A retrospective studyen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Medical Virologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0003-4930-8447en_US
dc.identifier.volume92en_US
dc.identifier.issue12en_US
dc.identifier.startpage2955en_US
dc.identifier.endpage2960en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1002/jmv.25734en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ2en_US


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