dc.contributor.author | Bektaş, Gonca | |
dc.contributor.author | Önal, Hasan | |
dc.contributor.author | Adal, Erdal | |
dc.date.accessioned | 2020-12-01T08:38:04Z | |
dc.date.available | 2020-12-01T08:38:04Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Bektaş, G., Önal, H. ve Adal, E. (2020). The factors relevant to partial remission in children with type 1 diabetes mellitus after measles vaccination: A retrospective study. Journal of Medical Virology, 92(12), 2955-2960. https://dx.doi.org/10.1002/jmv.25734 | en_US |
dc.identifier.issn | 0146-6615 | |
dc.identifier.issn | 1096-9071 | |
dc.identifier.uri | https://dx.doi.org/10.1002/jmv.25734 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/6067 | |
dc.description.abstract | We aimed to identify the determinants of partial remission in patients with type 1 diabetes mellitus (DM), and whether there is an influence of vaccination against measles on partial remission. This was a retrospective study consisting of consecutive patients diagnosed with type 1 DM followed-up from 1 September 2010, through 30 November 2011. The study included children vaccinated within 3 months after diagnosis, and children unvaccinated during the first 12 months of the disease. The daily insulin dose, hemoglobin A1c, and C-peptide levels, and whether children are in partial remission based on the insulin dose-adjusted HbA1c were recorded at diagnosis and 3, 6, 9, 12, 24, and 36 months. A total of 55 children with type 1 DM were analyzed. Thirty-one patients (56.4%) reached partial remission during the follow-up period, whereas 24 of them did not. Patients with diabetic ketoacidosis (DKA) at diagnosis were less likely to reach partial remission than patients without DKA (odds ratio [OR], 0.24; 95% confidence interval [CI], 0.062-0.946;P = .038). Patients vaccinated against measles were more likely to be in partial remission than patients unvaccinated (OR, 4.2; 95% CI, 1.35-13;P = .011). Partial remission was significantly associated with the C-peptide level and insulin dosage at diagnosisP = .002;P = .013, respectively). The lack of DKA, higher C-peptide level, and lower insulin dosage at diagnosis, and vaccination against measles after diagnosis may have an influence on partial clinical remission in patients with new-onset type 1 DM. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Immune System | en_US |
dc.subject | Immunomodulation | en_US |
dc.subject | Measles Virus | en_US |
dc.title | The factors relevant to partial remission in children with type 1 diabetes mellitus after measles vaccination: A retrospective study | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Medical Virology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-4930-8447 | en_US |
dc.identifier.volume | 92 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.startpage | 2955 | en_US |
dc.identifier.endpage | 2960 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1002/jmv.25734 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q2 | en_US |