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dc.contributor.authorSaka, Burcu
dc.contributor.authorMemiş, Bahar
dc.contributor.authorErbarut Seven, İpek
dc.contributor.authorPehlivanoğlu, Burçin
dc.contributor.authorBalcı, Serdar
dc.contributor.authorBağcı, Pelin
dc.contributor.authorReid, Michelle
dc.contributor.authorDursun, Nevra
dc.contributor.authorTapia Escalano, Oscar
dc.contributor.authorCarlos Roa, Juan
dc.contributor.authorCarlos Araya, Juan
dc.contributor.authorKong, So Yeon
dc.contributor.authorBaştürk, Olca
dc.contributor.authorKoshiol, Jill
dc.contributor.authorAdsay, N. Volkan
dc.date.accessioned2020-12-01T06:21:55Z
dc.date.available2020-12-01T06:21:55Z
dc.date.issued2020en_US
dc.identifier.citationSaka, B., Memiş, B., Erbarut Seven, İ., Pehlivanoğlu, B., Balcı, S., Bağcı, P. ... Adsay, N. V. (2020). Follicular cholecystitis: Reappraisal of incidence, definition, and clinicopathologic associations in an analysis of 2550 cholecystectomies. International Journal of Surgical Pathology, 28(8), 826-834. https://dx.doi.org/10.1177/1066896920924079en_US
dc.identifier.issn1066-8969
dc.identifier.issn1940-2465
dc.identifier.urihttps://dx.doi.org/10.1177/1066896920924079
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6061
dc.description.abstractContext.Follicular cholecystitis (FC) is a poorly characterized entity.Objective.To determine its frequency/clinicopathologic associations.Design.A total of 2550 cholecystectomy specimens were examined. Two hundred three of these were consecutive routine cholecystectomies submitted entirely for microscopic examination to determine the relative frequency of incidental pathologies in gallbladders (GBs). The remainder had representative sampling. Underlying conditions were nonobstructive pathologies (1270 nonspecific cholecystitis), obstructive (62 distal biliary tract tumors, 35 primary sclerosing cholangitis, and 31 autoimmune pancreatitis), and neoplastic (n = 949). FC was defined as 3 distinct lymphoid follicles (LFs)/centimeter.Results.In the GBs totally submitted for microscopic examination, the true frequency of FC was found to be 2.5% (5/203), and in the representatively sampled group, it was 1.9%, with similar frequencies in nonobstructive, obstructive, and neoplastic cases (2.3%, 3.1%, and 1.3%, respectively, P = .77). When the 39 FC in nonneoplastic GBs contrasted with ordinary chronic cholecystitis, they were associated with older age (68 vs 49 years, P < .0001), similar gallstone frequency (68 vs 81%), female/male ratio (2.7 vs 2.6), and wall thickness (4 mm for both). None had lymphoma/parasites/Salmonella infection. Of 17 cases who had undergone gastric biopsy, 5 had chronic gastritis (2 with Helicobacter pylori). Microscopically, the LFs were the main inflammatory process often with minimal intervening inflammation. IgG4-positive plasma cell density was low (<10/high-power field) in 21/24(87.5%) cases.Conclusions.Follicular cholecystitis is seen in 2% of cholecystectomies, typically in significantly older patients, suggesting a deranged immune response. A third of the patients reveal biopsy-proven gastritis. FC does not seem to be associated with autoimmunity, lymphoma, or obstructive pathologies.en_US
dc.language.isoengen_US
dc.publisherSAGE Publications Incen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectCholecystectomyen_US
dc.subjectFollicular Cholecystitisen_US
dc.subjectHistologyen_US
dc.titleFollicular cholecystitis: Reappraisal of incidence, definition, and clinicopathologic associations in an analysis of 2550 cholecystectomiesen_US
dc.typearticleen_US
dc.relation.ispartofInternational Journal of Surgical Pathologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-6830-7701en_US
dc.identifier.volume28en_US
dc.identifier.issue8en_US
dc.identifier.startpage826en_US
dc.identifier.endpage834en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1177/1066896920924079en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ3en_US


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