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dc.contributor.authorSürmen, Mustafa Gani
dc.contributor.authorSürmen, Saime
dc.contributor.authorAli, Arslan
dc.contributor.authorMusharraf, Syed Ghulam
dc.contributor.authorEmekli, Nesrin
dc.date.accessioned2020-11-26T07:26:16Z
dc.date.available2020-11-26T07:26:16Z
dc.date.issued2020en_US
dc.identifier.citationSürmen, M. G., Sürmen, S., Ali, A., Musharraf, S. G. ve Emekli, N. (2020). Phosphoproteomic strategies in cancer research: A minireview. Analyst, 145(22), 7125-7149. https://dx.doi.org/10.1039/d0an00915fen_US
dc.identifier.issn0003-2654
dc.identifier.issn1364-5528
dc.identifier.urihttps://dx.doi.org/10.1039/d0an00915f
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6054
dc.description.abstractUnderstanding the cellular processes is central to comprehend disease conditions and is also true for cancer research. Proteomic studies provide significant insight into cancer mechanisms and aid in the diagnosis and prognosis of the disease. Phosphoproteome is one of the most studied complements of the whole proteome given its importance in the understanding of cellular processes such as signaling and regulations. Over the last decade, several new methods have been developed for phosphoproteome analysis. A significant amount of these efforts pertains to cancer research. The current use of powerful analytical instruments in phosphoproteomic approaches has paved the way for deeper and sensitive investigations. However, these methods and techniques need further improvements to deal with challenges posed by the complexity of samples and scarcity of phosphoproteins in the whole proteome, throughput and reproducibility. This review aims to provide a comprehensive summary of the variety of steps used in phosphoproteomic methods applied in cancer research including the enrichment and fractionation strategies. This will allow researchers to evaluate and choose a better combination of steps for their phosphoproteome studies.en_US
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCancer Researchen_US
dc.subjectStrategiesen_US
dc.subjectPhosphoproteomicen_US
dc.titlePhosphoproteomic strategies in cancer research: A minireviewen_US
dc.typereviewen_US
dc.relation.journalAnalysten_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.identifier.volume145en_US
dc.identifier.issue22en_US
dc.identifier.startpage7125en_US
dc.identifier.endpage7149en_US
dc.relation.publicationcategoryDiğeren_US
dc.identifier.doi10.1039/d0an00915fen_US


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