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dc.contributor.authorKöksalar Alkan, Fulya
dc.contributor.authorKörkaya, Hasan
dc.date.accessioned2020-11-26T06:40:53Z
dc.date.available2020-11-26T06:40:53Z
dc.date.issued2020en_US
dc.identifier.citationKöksalar Alkan, F. ve Körkaya, H. (2020). Therapeutic utility of immunosuppressive TREM2+macrophages: An important step forward in potentiating the immune checkpoint inhibitors. Signal Transduction and Targeted Therapy, 5(1). https://dx.doi.org/10.1038/s41392-020-00383-5en_US
dc.identifier.issn2095-9907
dc.identifier.issn2059-3635
dc.identifier.urihttps://dx.doi.org/10.1038/s41392-020-00383-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6052
dc.description.abstractIn a recent article published in Cell, Molgora et al.1 reported that asubset of tumor-infiltrating macrophages with TREM2 expressioncreates an immunosuppressive microenvironment that promotestumor growth while suppressing anti-tumor immune responses.Targeting these TREM2+ macrophages via genetic ablation of thegene or specific antibodies against the protein reduces tumorgrowth in animal models; however, it further attenuates tumorgrowth when combined with immune checkpoint inhibitors (ICI)by promoting the expression of immunostimulatory molecules.en_US
dc.description.sponsorshipGeorgia Cancer Center startup fund ; American Cancer Society ; Bridge Fund by Augusta University Research Inc. ; Forbes Institute fund ; Evans County CARES funden_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectImmunosuppressiveen_US
dc.subjectTREM2+macrophagesen_US
dc.subjectCheckpoint Inhibitorsen_US
dc.titleTherapeutic utility of immunosuppressive TREM2+macrophages: An important step forward in potentiating the immune checkpoint inhibitorsen_US
dc.typearticleen_US
dc.relation.journalSignal Transduction and Targeted Therapyen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsüen_US
dc.authorid0000-0002-9520-6903en_US
dc.identifier.volume5en_US
dc.identifier.issue1en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1038/s41392-020-00383-5en_US


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