dc.contributor.author | Köksalar Alkan, Fulya | |
dc.contributor.author | Körkaya, Hasan | |
dc.date.accessioned | 2020-11-26T06:40:53Z | |
dc.date.available | 2020-11-26T06:40:53Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Köksalar Alkan, F. ve Körkaya, H. (2020). Therapeutic utility of immunosuppressive TREM2+macrophages: An important step forward in potentiating the immune checkpoint inhibitors. Signal Transduction and Targeted Therapy, 5(1). https://dx.doi.org/10.1038/s41392-020-00383-5 | en_US |
dc.identifier.issn | 2095-9907 | |
dc.identifier.issn | 2059-3635 | |
dc.identifier.uri | https://dx.doi.org/10.1038/s41392-020-00383-5 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/6052 | |
dc.description.abstract | In a recent article published in Cell, Molgora et al.1 reported that asubset of tumor-infiltrating macrophages with TREM2 expressioncreates an immunosuppressive microenvironment that promotestumor growth while suppressing anti-tumor immune responses.Targeting these TREM2+ macrophages via genetic ablation of thegene or specific antibodies against the protein reduces tumorgrowth in animal models; however, it further attenuates tumorgrowth when combined with immune checkpoint inhibitors (ICI)by promoting the expression of immunostimulatory molecules. | en_US |
dc.description.sponsorship | Georgia Cancer Center startup fund ; American Cancer Society ; Bridge Fund by Augusta University Research Inc. ; Forbes Institute fund ; Evans County CARES fund | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Nature | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Immunosuppressive | en_US |
dc.subject | TREM2+macrophages | en_US |
dc.subject | Checkpoint Inhibitors | en_US |
dc.title | Therapeutic utility of immunosuppressive TREM2+macrophages: An important step forward in potentiating the immune checkpoint inhibitors | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Signal Transduction and Targeted Therapy | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü | en_US |
dc.authorid | 0000-0002-9520-6903 | en_US |
dc.identifier.volume | 5 | en_US |
dc.identifier.issue | 1 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1038/s41392-020-00383-5 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |