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Toplam kayıt 11, listelenen: 1-10
An improved platform for cultured neuronal network electrophysiology: Multichannel optogenetics integrated with MEAs
(Springer, 2022)
Cultured neuronal networks (CNNs) are powerful tools for studying how neuronal representation and adaptation emerge in networks of controlled populations of neurons. To ensure the interaction of a CNN and an artificial ...
Phosphodiesterase 10A is a critical target for neuroprotection in a mouse model of ischemic stroke
(Springer, 2022)
Phosphodiesterase 10A (PDE10A) hydrolyzes adenosine 3 ',5 '-cyclic monophosphate (cAMP) and guanosine 3 ',5 '-cyclic monophosphate (cGMP). It is highly expressed in the striatum. Recent evidence implied that PDE10A may be ...
Oleamide, a sleep-inducing compound: Effects on Ion channels and cancer
(Mary Ann Liebert Inc., 2022)
Primary fatty acid amides (PFAMs) are interesting lipid-derived signaling molecules with wide-ranging actions, including bioelectric. In this perspective, we evaluate a possible triangular relationship: PFAMs-ion ...
Delayed therapeutic administration of melatonin enhances neuronal survival through AKT and MAPK signaling pathways following focal brain ischemia in mice
(Springer Nature, 2022)
Melatonin has a role in the cell survival signaling pathways as a candidate for secondary stroke prevention. Therefore, in the present study, the coordination of ipsilateral and contralateral hemispheres to evaluate delayed ...
Multiple sclerosis biomarker candidates revealed by cell-type-specific interactome analysis
(Mary Ann Liebert, 2022)
Multiple sclerosis (MS) is a demyelinating disorder that affects multiple regions of the central nervous system such as the brain, spinal cord, and optic nerves. Susceptibility to MS, as well as disease progression rates, ...
A microwave-powered continuous fluidic system for polymer nanocomposite manufacturing: A proof-of-concept study
(Royal Society of Chemistry, 2022)
Continuous manufacturing of pure nanocrystals with a narrow size distribution in a polymer matrix is very challenging, although it is highly crucial to get their full potential for advanced applications. A long-lasting ...
Biological evaluation of imidazopyridine derivatives as potential anticancer agents against breast cancer cells
(Springer, 2022)
Imidazo[1,2-a]pyridine cores have increasing importance in the pharmaceutical industry with their wide range pharmacological activities. In this study, two series of imidazopyridine derivatives were synthesized. It was ...
Ion Channel Modulation Symposium (Sophion Bioscience) June 22nd-23rd, 2022, Clare College, Cambridge, United Kingdom
(Mary Ann Liebert Inc., 2022)
This popular meeting occurred for the fifth time, returning after a 2-year break, with some 150 people attending to fill the maximum capacity. The proceedings included 22 oral presentations and 15 posters, altogether ...
Culturing, freezing, processing, and imaging of entire organoids and spheroids while still in a hydrogel
(Journal of Visualized Experiments, 2022)
Organoids and spheroids, three-dimensional growing structures in cell culture labs, are becoming increasingly recognized as superior models compared to two-dimensional culture models, since they mimic the human body better ...
Inhibition of SARS-CoV-2 main protease: A repurposing study that targets the dimer interface of the protein
(Taylor and Francis Ltd., 2022)
Coronavirus disease-2019 (COVID-19) was firstly reported in Wuhan, China, towards the end of 2019, and emerged as a pandemic. The spread and lethality rates of the COVID-19 have ignited studies that focus on the development ...