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Toplam kayıt 21, listelenen: 1-10
Predicting the effects of repetitive transcranial magnetic stimulation on cognitive functions in patients with alzheimer's disease by automated EEG analysis
(Frontiers Media SA, 2022)
Alzheimer's disease (AD) is a progressive, neurodegenerative brain disorder that generally affects the elderly. Today, after the limited benefit of the pharmacological treatment strategies, numerous noninvasive brain ...
Temperature and pH-dependent behaviors of mAb drugs: A case study for trastuzumab
(MDPI, 2022)
The distortions in the high-order structure of therapeutic monoclonal antibodies (mAbs) under different environmental conditions acutely affect mAb stability, resulting in altered safety, efficacy, and shelf-life profiles. ...
Ghrelin regulates expression of the transcription factor Pax6 in hypoxic brain progenitor cells and neurons
(MDPI, 2022)
The nature of brain impairment after hypoxia is complex and recovery harnesses different mechanisms, including neuroprotection and neurogenesis. Experimental evidence suggests that hypoxia may trigger neurogenesis postnatally ...
Stratification of the gut microbiota composition landscape across the alzheimer's disease continuum in a Turkish cohort
(American Society for Microbiology, 2022)
Alzheimer's disease (AD) is a heterogeneous disorder that spans a continuum with multiple phases, including preclinical, mild cognitive impairment, and dementia. Unlike for most other chronic diseases, human studies reporting ...
Telling functional networks apart using ranked network features stability
(NLM (Medline), 2022)
Over the past few years, it has become standard to describe brain anatomical and functional organisation in terms of complex networks, wherein single brain regions or modules and their connections are respectively identified ...
Enhancing memory capacity by experimentally slowing theta frequency oscillations using combined EEG-tACS
(Nature Portfolio, 2022)
he coupling of gamma oscillation (similar to 40+ Hz) amplitude to the phase of ongoing theta (similar to 6 Hz) oscillations has been proposed to be directly relevant for memory performance. Current theories suggest that ...
Chemogenetic inhibition of MCH neurons does not alter memory performance in mice
(Elsevier Masson s.r.l., 2022)
Memory storage in the brain is one of the most extensively studied subjects in neuroscience. However, due to the highly complex structure of the memory-related systems in the brain, the mystery remains unsolved. Consolidation ...
Striatal dopaminergic neurons as a potential target for GDNF based ischemic stroke therapy
(Turkey Clinics, 2022)
Background/aim: Glial cell-line-derived neurotrophic factor (GDNF) is a well-known regulatory neurotrophic factor on dopaminergic neurons. Several pathologies have been documented so far in case of any impairment in the ...
Potential of novel methyl jasmonate analogs as anticancer agents to metabolically target HK-2 activity in glioblastoma cells
(Frontiers Media S.A., 2022)
Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, ...
Lithium promotes long-term neurological recovery after spinal cord injury in mice by enhancing neuronal survival, gray and white matter remodeling, and long-distance axonal regeneration
(Frontiers Media S.A., 2022)
Spinal cord injury (SCI) induces neurological deficits associated with long-term functional impairments. Since the current treatments remain ineffective, novel therapeutic options are needed. Besides its effect on bipolar ...