Yazar "Doeppner, Thorsten R." için Makale Koleksiyonu listeleme
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Age-associated resilience against ischemic injury in mice exposed to transient middle cerebral artery occlusion
Beker, Mustafa Çağlar; Aydınlı, Fatmagül İlayda; Çağlayan, Ahmet Burak; Beker, Merve; Baygül, Oğuzhan; Çağlayan, Aysun; Popa-Wagner, Aurel; Doeppner, Thorsten R.; Hermann, Dirk M.; Kılıç, Ertuğrul (Springer, 2023)Ischemic stroke is the leading cause of death and disability. Although stroke mainly affects aged individuals, animal research is mostly one on young rodents. Here, we examined the development of ischemic injury in young ... -
Developing a novel tool to assess the ability to self-administer medication - A systematic evaluation of patients' video recordings in the ABLYMED study
Luegering, Anneke; Langner, Robert; Wilm, Stefan; Doeppner, Thorsten R.; Hermann, Dirk M.; Frohnhofen, Helmut; Gronewold, Janine (Frontiers Media S.A., 2023)Background: Older people often experience medication management problems due to multimorbidity, polypharmacy and medication complexity. There is often a large gap between patients' self-reported and actual abilities to ... -
In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model
Kelmanson, Ilya V.; Shokhina, Arina G.; Kotova, Daria A.; Pochechuev, Matvei S.; Ivanovaa, Alexandra D.; Kostyuka, Alexander I.; Panova, Anastasiya S.; Borodinova, Anastasia A.; Solotenkovc, Maxim A.; Stepanov, Evgeny A.; Raevskiia, Roman I.; Moshchenko, Aleksandr A.; Pak, Valeriy V.; Ermakova, Yulia G.; van Belle, Gijsbert J.C.; Tarabykin, Viktor; Balaban, Pavel M.; Fedotov, Ilya V.; Fedotov, Andrei B.; Conrad, Marcus; Bogeski, Ivan; Katschinski, Dörthe M.; Doeppner, Thorsten R.; Bähr, Mathias; Zheltikov, Aleksei M.; Belousov, Vsevolod V.; Bilan, Dmitry S. (Elsevier B.V., 2021)Ischemic cerebral stroke is one of the leading causes of death and disability in humans. However, molecular processes underlying the development of this pathology remain poorly understood. There are major gaps in our ... -
Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism
Doeppner, Thorsten R.; Coman, Cristin; Burdusel, Daiana; Ancuta, Diana Larisa; Brockmeier, Ulf; Pirici, Daniel Nicolae; Kuang Yaoyun; Hermann, Dirk M.; Popa Wagner, Aurel (Impact Journals LLC, 2022)Previous studies have shown that the polyamine spermidine increased the maximum life span in C. elegans and the median life span in mice. Since spermidine increases autophagy, we asked if treatment with chloroquine, an ...