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Toplam kayıt 212, listelenen: 21-30
What a single electroencephalographic (EEG) channel can tell us about patients with dementia due to Alzheimer's disease
(Elsevier B.V., 2022)
Abnormalities in cortical sources of resting-state eyes-closed electroencephalographic (rsEEG) rhythms recorded by hospital settings (10–20 electrode montage) with 19 scalp electrodes provide useful markers of neurophysiological ...
Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target
(American Society for Biochemistry and Molecular Biology Inc., 2021)
Hexokinase (HK) catalyzes the first step in glucose metabolism, making it an exciting target for the inhibition of tumor initiation and progression due to their elevated glucose metabolism. The upregulation of hexokinase-2 ...
In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model
(Elsevier B.V., 2021)
Ischemic cerebral stroke is one of the leading causes of death and disability in humans. However, molecular processes underlying the development of this pathology remain poorly understood. There are major gaps in our ...
Upcycling of industrial iron scale waste for reutilization as anode material in lithium ion batteries
(Elsevier Ltd, 2022)
In this work, iron scale is used as the starting raw material to produce anode for lithium ion batteries. In this scope, three different samples are fabricated, then their properties are investigated to evaluate their ...
Chemogenetic approaches to dissect the role of H2O2 in redox-dependent pathways using genetically encoded biosensors
(Portland Press Ltd, 2022)
Chemogenetic tools are recombinant enzymes that can be targeted to specific organelles and tissues. The provision or removal of the enzyme substrate permits control of its biochemical activities. Yeast-derived enzyme D-amino ...
Integrin α5β1 mediated cellular reorganization in human mesenchymal stem cells during neuronal differentiation
(International Institute of Anticancer Research, 2021)
Background/Aim: Mesenchymal stem cells (MSCs) have been widely used for yielding neurons in culture to study nervous system pathologies and develop regenerative approaches. In this study, cellular rearrangements of human ...
Are there consistent abnormalities in event-related EEG oscillations in patients with Alzheimer's disease compared to other diseases belonging to dementia?
(John Wiley and Sons Inc, 2022)
Cerebrospinal and structural-molecular neuroimaging in-vivo biomarkers are recommended for diagnostic purposes in Alzheimer’s disease (AD) and other dementias; however, they do not explain the effects of AD neuropathology ...
Ghrelin regulates expression of the transcription factor Pax6 in hypoxic brain progenitor cells and neurons
(MDPI, 2022)
The nature of brain impairment after hypoxia is complex and recovery harnesses different mechanisms, including neuroprotection and neurogenesis. Experimental evidence suggests that hypoxia may trigger neurogenesis postnatally ...
Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer
(Elsevier B.V., 2022)
Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ...
Phosphorylation of PI3K/Akt at Thr308, but not phosphorylation of MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice
(Academic Press Inc., 2022)
Lithium, in addition to its effect on acute and long-term bipolar disorder, is involved in neuroprotection after ischemic stroke. Yet, its mechanism of action is still poorly understood, which was only limited to its ...