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Toplam kayıt 67, listelenen: 41-50
Functional evaluation of the tachycardia patient-derived iPSC cardiomyocytes carrying a novel pathogenic SCN5A variant
(Wiley, 2022)
Tachycardia is characterized by high beating rates that can lead to life-threatening fibrillations. Mutations in several ion-channel genes were implicated with tachycardia; however, the complex genetic contributors and ...
Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines
(Elsevier Inc., 2022)
Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of ...
Defining optimal enzyme and matrix combination for replating of human induced pluripotent stem cell-derived cardiomyocytes at different levels of maturity
(Elsevier Inc., 2021)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) create an unlimited cell source for basic and translational research. Depending on the maturity of cardiac cultures and the intended applications, ...
Anatomical characterization of vagal nodose afferent innervation and ending morphologies at the murine heart using a transgenic approach
(Elsevier B.V., 2022)
Heart is an extensively innervated organ and its function is strictly coordinated by autonomic neural circuits. After pathological events such as myocardial infarction (MI), cardiac nerves undergo a structural and functional ...
A rational design of multi-functional nanoplatform: Fluorescent-based “off-on” theranostic gold nanoparticles modified with D-α-Tocopherol succinate
(Elsevier B.V., 2021)
It is crucial to develop nanocarrier systems to detect and treat drug-resistant micro tumors to prevent recurrence and/or metastasis of cancer. Due to their exceptional features such as biocompatibility, easy surface ...
Lamotrigine derivatives-synthesis, anti-cancer, and anti-MDR-bacterial activities
(Elsevier B.V., 2022)
A new series of quaternary ammonium salts 3–21 of lamotrigine (6-(2, 3-dichlorophenyl)-1, 2, 4-triazine-3, 5-diamine) was synthesized via N-alkylation of lamotrigine using different benzyl bromides. The new analogues were ...
Evaluation of the bilateral cardiac afferent distribution at the spinal and vagal ganglia by retrograde labeling
(Elsevier, 2021)
The identity of sensory neurons innervating the heart tissue and the extent of information reported to the brain via these neurons are poorly understood. In order to evaluate the multidimensional distribution and abundance ...
Design of IKVAV peptide/gold nanoparticle decorated, micro/nano-channeled PCL/PLGA film scaffolds for neuronal differentiation and neurite outgrowth
(Elsevier Ltd, 2023)
In the field of neural tissue engineering, intensive efforts are being made to develop tissue scaffolds that can support an effective functional recovery and neural development by guiding damaged axons and neurites. ...
Event-related brain oscillatory responses topographically differentiated between visual and auditory emotional stimuli
(Elsevier, 2023)
Previous EEG studies using emotional stimuli have successfully demonstrated that EEG-brain oscillation responses are sensitive to the valance and arousal of the stimulus. While the valance is represented by increased beta ...
Resting state electroencephalographic alpha rhythms predict and are sensitive to Alzheimer's disease mild cognitive impairment progression at a 6-month follow-up
(Elsevier, 2023)
Introduction: Patients with Alzheimer’s disease and mild cognitive impairment (ADMCI) suffer not only from severe cognitive deficits and disabilities in daily living but also from vigilance dysregulation reflected by ...