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Toplam kayıt 205, listelenen: 71-80
Chronic unpredictable stress disturbs the blood-testis barrier affecting sperm parameters in mice
(Elsevier Ltd, 2021)
Research question: Does chronic stress affect the key proteins and sperm parameters of the blood & ndash;testis barrier (BTB)? Design: C57Bl/6 mice were divided into two groups: a non-treated control group and a chronic ...
Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism
(Impact Journals LLC, 2022)
Previous studies have shown that the polyamine spermidine increased the maximum life span in C. elegans and the median life span in mice. Since spermidine increases autophagy, we asked if treatment with chloroquine, an ...
Probing subcellular iron availability with genetically encoded nitric oxide biosensors
(MDPI (Multidisipliner Digital Publishing Institute), 2022)
Cellular iron supply is required for various biochemical processes. Measuring bioavailable iron in cells aids in obtaining a better understanding of its biochemical activities but is technically challenging. Existing ...
Emerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke
(Ivyspring International Publisher, 2022)
Hypoxia is a central pathophysiological component in cancer, myocardial infarction and ischemic stroke, which represent the most common medical conditions resulting in long-term disability and death. Recent evidence suggests ...
Ion Channel Modulation Symposium (Sophion Bioscience) June 22nd-23rd, 2022, Clare College, Cambridge, United Kingdom
(Mary Ann Liebert Inc., 2022)
This popular meeting occurred for the fifth time, returning after a 2-year break, with some 150 people attending to fill the maximum capacity. The proceedings included 22 oral presentations and 15 posters, altogether ...
Culturing, freezing, processing, and imaging of entire organoids and spheroids while still in a hydrogel
(Journal of Visualized Experiments, 2022)
Organoids and spheroids, three-dimensional growing structures in cell culture labs, are becoming increasingly recognized as superior models compared to two-dimensional culture models, since they mimic the human body better ...
Neuropsychiatric outcomes and caregiver distress in primary progressive aphasia
(Wiley, 2023)
Background: In this study, we aimed to outline the neuropsychiatric consequences of primary progressive aphasia (PPA) and to understand how neuropsychiatric symptomatology affects distress in caregivers. Methods: The ...
Inhibition of SARS-CoV-2 main protease: A repurposing study that targets the dimer interface of the protein
(Taylor and Francis Ltd., 2022)
Coronavirus disease-2019 (COVID-19) was firstly reported in Wuhan, China, towards the end of 2019, and emerged as a pandemic. The spread and lethality rates of the COVID-19 have ignited studies that focus on the development ...
PEGylated reduced graphene oxide as nanoplatform for targeted gene and drug delivery
(Elsevier Ltd, 2023)
Combination therapies involving anticancer drugs and gene therapy agents have become a potential treatment for different cancer types reducing the side effects of anticancer drugs while enhancing their effectiveness. Here, ...
Oxide glass formers extending persistent luminescence in Eu and Dy co-doped strontium aluminates
(Elsevier B.V., 2023)
Recent work has shown that the incorporation of electrically charged, non-bridging oxygen (NBO) species into Eu and Dy co-doped Sr4Al14O25 (S4A7ED) crystal structure, in the form of BØ2O−, induces the clustering of divalent ...