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Toplam kayıt 72, listelenen: 41-50
Quest for quality in translational stroke research––a new dawn for neuroprotection?
(Multidisciplinary Digital Publishing Institute, 2022)
Despite tremendous progress in modern‐day stroke therapy, ischemic stroke remains a disease associated with a high socioeconomic burden in industrialized countries. In light of demo-graphic change, these health care costs ...
Biological evaluation of imidazopyridine derivatives as potential anticancer agents against breast cancer cells
(Springer, 2022)
Imidazo[1,2-a]pyridine cores have increasing importance in the pharmaceutical industry with their wide range pharmacological activities. In this study, two series of imidazopyridine derivatives were synthesized. It was ...
Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism
(Impact Journals LLC, 2022)
Previous studies have shown that the polyamine spermidine increased the maximum life span in C. elegans and the median life span in mice. Since spermidine increases autophagy, we asked if treatment with chloroquine, an ...
Probing subcellular iron availability with genetically encoded nitric oxide biosensors
(MDPI (Multidisipliner Digital Publishing Institute), 2022)
Cellular iron supply is required for various biochemical processes. Measuring bioavailable iron in cells aids in obtaining a better understanding of its biochemical activities but is technically challenging. Existing ...
Emerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke
(Ivyspring International Publisher, 2022)
Hypoxia is a central pathophysiological component in cancer, myocardial infarction and ischemic stroke, which represent the most common medical conditions resulting in long-term disability and death. Recent evidence suggests ...
Ion Channel Modulation Symposium (Sophion Bioscience) June 22nd-23rd, 2022, Clare College, Cambridge, United Kingdom
(Mary Ann Liebert Inc., 2022)
This popular meeting occurred for the fifth time, returning after a 2-year break, with some 150 people attending to fill the maximum capacity. The proceedings included 22 oral presentations and 15 posters, altogether ...
Culturing, freezing, processing, and imaging of entire organoids and spheroids while still in a hydrogel
(Journal of Visualized Experiments, 2022)
Organoids and spheroids, three-dimensional growing structures in cell culture labs, are becoming increasingly recognized as superior models compared to two-dimensional culture models, since they mimic the human body better ...
Inhibition of SARS-CoV-2 main protease: A repurposing study that targets the dimer interface of the protein
(Taylor and Francis Ltd., 2022)
Coronavirus disease-2019 (COVID-19) was firstly reported in Wuhan, China, towards the end of 2019, and emerged as a pandemic. The spread and lethality rates of the COVID-19 have ignited studies that focus on the development ...
Novel β‑hydroxy ketones: Synthesis, spectroscopic characterization, molecular docking, and anticancer activity studies
(Elsevier B. V., 2022)
In this study, a series of novel β‑hydroxy ketone derivatives 3a-o were designed, synthesized, and evaluated for their anticancer activity. The structure of these compounds were characterized by IR, 1H and 13C NMR, mass ...
Phosphodiesterase 10A deactivation induces long-term neurological recovery, peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice
(Academic Press Inc., 2022)
The phosphodiesterase (PDE) superfamily comprises enzymes responsible for the cAMP and cGMP degradation to AMP and GMP. PDEs are abundant in the brain, where they are involved in several neuronal functions. High PDE10A ...