Erişim şekli için "https://creativecommons.org/licenses/by-nc-nd/4.0/" Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü (SABİTA) listeleme
Toplam kayıt 14, listelenen: 1-14
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Active shrinkage protects neurons following axonal transection
(Elsevier Inc., 2023)Trauma, vascular events, or neurodegenerative processes can lead to axonal injury and eventual transection (axotomy). Neurons can survive axotomy, yet the underlying mechanisms are not fully understood. Excessive water ... -
Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response
(2024)Programmed death ligand 1, PD-L1 (CD274), facilitates immune evasion and exerts pro-survival functions in cancer cells. Here, we report a mechanism whereby internalization of PD-L1 in response to alterations of bioactive ... -
The effects of gold nanoparticles with different surface coatings and sizes on biochemical parameters in mice
(Prusa Medical Publishing, 2023)Objectives: Gold nanoparticles are very popular metallic nanomaterials and they have a wide spectrum of biomedical applications. This study was aimed to the production of stable and monodisperse polyethyleneimine (PEI) and ... -
Experimental data of labeling the heart and cardiac cultures with a retrograde tracer in vitro and in vivo
(Elsevier Inc., 2021)Retrograde dyes are often used in basic research to investigate neuronal innervations of an organ. This article describes the experimental data on the application of retrograde dyes on the mouse heart in vivo and on the ... -
Identification of PDE10A related proteins via proteomic analysis
(İnönü University Faculty of Medicine, 2022)Aim: Phosphodiesterase 10A (PDE10A) regulates the expression of secondary messengers of cyclic adenosine monophosphate and cyclic guanosine monophosphate, which control several intracellular signaling pathways. Recently, ... -
In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model
(Elsevier B.V., 2021)Ischemic cerebral stroke is one of the leading causes of death and disability in humans. However, molecular processes underlying the development of this pathology remain poorly understood. There are major gaps in our ... -
Investigation of the relationship between upper limb apraxia and neuropsychological profile in alzheimer’s disease dementia and mild cognitive impairment
(2024)Objectives: This study aimed to examine the differences in upper limb apraxia assessments and neuropsychological profiles of patients diagnosed with Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI) and ... -
Leaching of iron and chromium from an indigenous ferro chromium alloy via a rotary evaporator: Optimum conditions determination and kinetic analysis
(Elsevier, 2020)In the leaching process of chromium-containing precursor hexavalent chromium may form, which provokes damages to environment and human health. As a solution, leaching the chromium containing precursor with sulphuric acid ... -
Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer
(Elsevier B.V., 2022)Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ... -
Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels
(Elsevier B.V., 2022)Iron is an essential metal for cellular metabolism and signaling, but it has adverse effects in excess. The physiological consequences of iron deficiency are well established, yet the relationship between iron supplementation ... -
A proteomic analysis for profiling NeuroD2 related changes in N2A neuroblastoma cell line
(Inönü University Faculty of Medicine, 2023)Aim: NeuroD2 transcription factor is a key regulator of neurogenin-NeuroD signaling network and induces neuronal development, differentiation, neurogenesis and calcium de- pendent signaling. NeuroD2 regulates expression ... -
TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury
(Elsevier Masson s.r.l., 2024)Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane receptor protein predominantly expressed in microglia within the central nervous system (CNS). TREM2 regulates multiple microglial functions, ... -
Üstün zekâlı çocukların annelerinin gebelik sürecindeki beslenme alışkanlıklarının saptanması: Retrospektif bir çalışma
(Türkiye Klinikleri, 2023)Amaç: Bu araştırmada, üstün zekâlı çocuğu olan annelerin gebelik dönemindeki beslenme al ışkanlıklarının araştırılması ve kontrol grubu ile karşılaştırılması amaçlanmıştır. Gereç ve Yöntemler: Retrospektif ve ta- nımlayıcı ...