ORCID "0000-0001-8089-1330" Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü (SABİTA) için listeleme
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Active shrinkage protects neurons following axonal transection
Aydın, Mehmet Şerif; Bay, Sadık; Yiğit, Esra Nur; Özgül, Cemil; Kaval Oğuz, Elif; Yenidünya Konuk, Elçin; Ayşit, Neşe; Cengiz, Nureddin; Erdoğan, Ender; Him, Aydın; Koçak, Mehmet; Eroğlu, Emrah; Öztürk, Gürkan (Elsevier Inc., 2023)Trauma, vascular events, or neurodegenerative processes can lead to axonal injury and eventual transection (axotomy). Neurons can survive axotomy, yet the underlying mechanisms are not fully understood. Excessive water ... -
Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl
Bay, Sadık; Öztürk, Gürkan; Emekli, Nesrin; Demircan, Turan (Elsevier Inc., 2023)The Hippo pathway plays an imperative role in cellular processes such as differentiation, regeneration, cell migration, organ growth, apoptosis, and cell cycle. Transcription coregulator component of Hippo pathway, YAP1, ... -
Network-medicine approach for the identification of genetic association of parathyroid adenoma with cardiovascular disease and type-2 diabetes
İmam, Nikhat; Alam, Aftab; Siddiqui, Mohd Faizan; Veg, Akhtar; Bay, Sadık; Khan, Md Jawed Ikbal; Ishrat, Romana (Oxford University Press, 2023)Primary hyperparathyroidism is caused by solitary parathyroid adenomas (PTAs) in most cases (⁓85%), and it has been previously reported that PTAs are associated with cardiovascular disease (CVD) and type-2 diabetes (T2D). ... -
Neuroprotective effects of curcumin-loaded emulsomes in a laser axotomy-induced CNS injury model
Yılmaz, Elif Nur; Bay, Sadık; Öztürk, Gürkan; Uçışık, Mehmet Hikmet (Dove Medical Press Ltd, 2020)Purpose: Curcumin, a polyphenol isolated from the rhizomes of turmeric, holds great potential as a neuroprotective agent in addition to its anti-inflammatory and antioxidant characteristics. The poor bioavailability and ... -
Potential of novel methyl jasmonate analogs as anticancer agents to metabolically target HK-2 activity in glioblastoma cells
Uludağ, Damla; Bay, Sadık; Onur Sucu, Bilgesu; Şavluğ İpek, Özgecan; Mohr, Thomas; Güzel, Mustafa; Karakaş, Nihal (Frontiers Media S.A., 2022)Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, ... -
Zero-valent iron nanoparticles containing nanofiber scaffolds for nerve tissue engineering
Aydemir Sezer, Ümran; Öztürk Yavuz, Kevser; Örs, Gizem; Bay, Sadık; Aru, Başak; Söğüt, Oğuz; Akgül Çağlar, Tuba; Bozkurt, Mehmet Recep; Çağavi, Esra; Yanıkkaya Demirel, Gülderen; Sezer, Serdar; Karaca, Hüseyin (Wiley, 2020)Regeneration of nerve tissue is a challenging issue in regenerative medicine. Especially, the peripheral nerve defects related to the accidents are one of the leading health problems. For large degeneration of peripheral ...