Yazar "Mansoor, Samman" için Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü (SABİTA) listeleme
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Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target
Ferreira, Juliana C.; Khrbtli, Abdul Rahman; Shetler, Cameron L.; Mansoor, Samman; Ali, Liaqat; Şensoy, Özge; Rabeh, Wael M. (American Society for Biochemistry and Molecular Biology Inc., 2021)Hexokinase (HK) catalyzes the first step in glucose metabolism, making it an exciting target for the inhibition of tumor initiation and progression due to their elevated glucose metabolism. The upregulation of hexokinase-2 ... -
Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer
Mansoor, Samman; Kayık, Gülru; Durdağı, Serdar; Şensoy, Özge (Elsevier B.V., 2022)Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ...