Show simple item record

dc.contributor.authorRamadan, Saime
dc.contributor.authorSaka, Burcu
dc.contributor.authorYarıkkaya, Enver
dc.contributor.authorBilici, Ahmet
dc.contributor.authorÖncel, Mustafa
dc.date.accessioned2020-11-12T07:16:54Z
dc.date.available2020-11-12T07:16:54Z
dc.date.issued2020en_US
dc.identifier.citationRamadan, S., Saka, B., Yarıkkaya, E., Bilici, A. ve Öncel, M. (2020). The potential prognostic role of peritumoral eosinophils within whole tumor-associated inflammatory cells and stromal histological characteristics in colorectal cancer. Polish Journal of Pathology, 71(3), 207-220. https://dx.doi.org/10.5114/PJP.2020.99787en_US
dc.identifier.issn1233-9687
dc.identifier.urihttps://dx.doi.org/10.5114/PJP.2020.99787
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6013
dc.description.abstractWe aimed to determine the prognostic role of whole tumor-associated inflammatory cells, especially eosinophils, and stromal histological characteristics in relation to other prognostic parameters in patients with colorectal carcinoma (CRC). A total of 122 patients who underwent an operation for CRC were included in this retrospective study. Conventional (tumor grade, TNM stage and venous invasion [VI]) and other histopathological (intratumoral/peritumoral budding {ITB/PTB], desmoplasia) tumor parameters were recorded and classified by density, as were the tumor-associated inflammatory parameters (intratumoral/peritumoral lymphocytes {ITL/PTL], eosinophils [IE/PTE], overall inflammation [ITI/PTI], Crohn-like inflammation [CLI]). Cancer-specific survival data were analyzed with respect to all tumor parameters. High ITB and PTB were significantly correlated with a higher rate of pT4, VI and desmoplasia (p < 0.05). An association of moderate ITL and extensive PTL with lesser likelihood of VI and metastasis; an association of extensive CLI with a significantly lower rate of metastasis and TNM stage IV; and minimal PTE with a significantly higher rate of pT4 stage, metastasis and ITB were detected (p < 0.05 for each). Our findings revealed that low score tumoral budding and an increase in tumor-related inflammation were associated with lesser likelihood of poor prognostic tumor parameters. Nonetheless, given the association of an increase in PTE with lesser likelihood of ITB, pT4, metastasis, and with non-significantly for better survival rates, our findings emphasize the potential role of peritumoral eosinophils as an additional prognostic parameter in CRC.en_US
dc.language.isoengen_US
dc.publisherVesalius University Medical Publisheren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColorectal Canceren_US
dc.subjectSurvivalen_US
dc.subjectTumor-Related Inflammationen_US
dc.subjectTumor Buddingen_US
dc.titleThe potential prognostic role of peritumoral eosinophils within whole tumor-associated inflammatory cells and stromal histological characteristics in colorectal canceren_US
dc.typearticleen_US
dc.relation.journalPolish Journal of Pathologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.authorid0000-0001-6830-7701en_US
dc.authorid0000-0003-2357-5387en_US
dc.identifier.volume71en_US
dc.identifier.issue3en_US
dc.identifier.startpage207en_US
dc.identifier.endpage220en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5114/PJP.2020.99787en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record