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dc.contributor.authorYetkin Yıldırım, Gonca
dc.contributor.authorTola, Esra Nur
dc.contributor.authorDağ, İsmail
dc.date.accessioned2020-10-20T05:58:32Z
dc.date.available2020-10-20T05:58:32Z
dc.date.issued2020en_US
dc.identifier.citationYetkin Yıldırım, G., Tola, E. N. ve Dağ, İ. (2020). A novel biochemical marker-OKL38- with its apoptotic and antioxidant properties for the development of PCOS and its related clinical implications. Gynecological Endocrinology, 36(8), 673-677. https://dx.doi.org/10.1080/09513590.2020.1718641en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.urihttps://dx.doi.org/10.1080/09513590.2020.1718641
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5935
dc.description.abstractAim: To investigate the role of serum OKL38 levels in the development of polycystic ovary syndrome (PCOS) and clinical implications related to PCOS. Method: PCOS (n = 33) and ovulatory controls (n = 48) were recruited for the study. Anthropometric measurements were recorded, and blood samples for hormonal and biochemical parameters including serum OKL38 levels were obtained. The potential role of OKL38 on the development of PCOS, metabolic syndrome and cardiovascular disease (CVD) were investigated. Framingham risk score (FRS) was used for the determination of CVD risk. Results: Mean Ferriman-Gallway (FG) score, insulin, low-density lipoprotein (LDL), total cholesterol (TC) levels, and the homeostasis model assessment of insulin resistance index (HOMA-IR) were significantly increased (p < .05) in women with PCOS compared to controls. PCOS group had lower mean OKL38 level compared to controls (p < .0001) and OKL38 was negatively predictive for the diagnosis of PCOS after adjustment of variables that were significantly different between two groups. A negative association between OKL38 and metabolic syndrome in PCOS women was evident after adjustment for age, obesity, and abdominal obesity. OKL38 level was also negatively correlated with body mass index, waist-to-hip-ratio, fat composition, serum TC, LDL, free testosterone levels, FRS, and FG scores. Conclusion: OKL38 may have a partial role in the etiopathogenesis of PCOS and may protect development of metabolic syndrome and CVD in women with PCOS.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectPCOSen_US
dc.subjectOKL38en_US
dc.subjectMetabolic Syndromeen_US
dc.subjectCardiovascular Disease Risken_US
dc.titleA novel biochemical marker-OKL38- with its apoptotic and antioxidant properties for the development of PCOS and its related clinical implicationsen_US
dc.typearticleen_US
dc.relation.journalGynecological Endocrinologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.identifier.volume36en_US
dc.identifier.issue8en_US
dc.identifier.startpage673en_US
dc.identifier.endpage677en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1080/09513590.2020.1718641en_US


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