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dc.contributor.authorOğlakçı İlhan, Ayşegül
dc.contributor.authorÖzkoç, Mustafa Furkan
dc.contributor.authorKuşat Ol, Kevser
dc.contributor.authorKarimkhani, Hadi
dc.contributor.authorŞentürk, Hakan
dc.contributor.authorBurukoğlu, Dilek
dc.contributor.authorKanbak, Güngör
dc.date.accessioned2020-10-12T10:49:17Z
dc.date.available2020-10-12T10:49:17Z
dc.date.issued2020en_US
dc.identifier.citationOğlakçı İlhan, A., Özkoç, M. F., Kuşat Ol, K., Karimkhani, H., Şentürk, H., Burukoğlu, D. ... Kanbak, G. (2020). Protective effect of betaine against skeleton muscle apoptosis in rats induced by chronic alcohol and statin consumption. Bratislava Medical Journal-Bratislavske Lekarske Listy, 121(8), 589-599. https://dx.doi.org/10.4149/BLL_2020_098en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2020_098
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5913
dc.description.abstractAIM: The aim of the present study was to investigate the effect of apoptosis on rat skeletal muscle caused by chronic alcohol and statin consumption with modified liquid diet and to elucidate protective effects of betaine supplementation.METHODS: TNF-alpha (tumor necrosis factor), NF-kappa B (Nuclear Factor kappa B), cytochrome c and caspase-3 levels with or without betaine treatment in alcohol and/or statin-induced skeleton muscle apoptosis rats as well as in controls were measured in serum and tissue. Histologic examinations of the muscle tissues were also performed.RESULTS: In our study, betaine treated treatment groups we found that calpain and caspase activities and cytokine c release were decreased caused by alcohol, statin and more importantly alcohol+statin group and TNF and NF-kappa B levels were also close to the levels of control group. Similarly, significant improvements have been observed in our morphological and histological examination results also supporting our biochemical data.CONCLUSION: We found that combined consumption of ethanol and statin is capable of triggering apoptotic cell death in rat muscles more than the consumption of only alcohol or only statin. Betaine was able to reduced this muscle cell death induced by alcohol and/or statin consumption.en_US
dc.language.isoengen_US
dc.publisherComenius Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlcoholen_US
dc.subjectStatinen_US
dc.subjectRaten_US
dc.subjectMuscleen_US
dc.subjectApoptosisen_US
dc.titleProtective effect of betaine against skeleton muscle apoptosis in rats induced by chronic alcohol and statin consumptionen_US
dc.typearticleen_US
dc.relation.journalBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.identifier.volume121en_US
dc.identifier.issue8en_US
dc.identifier.startpage589en_US
dc.identifier.endpage599en_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/114S241
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.4149/BLL_2020_098en_US


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