dc.contributor.author | Bener, Abdulbari | |
dc.contributor.author | Dafeeah, Elnour Elnaem | |
dc.contributor.author | Abou-Saleh, Mohammed T. | |
dc.contributor.author | Bhugra, Dinesh | |
dc.contributor.author | Ventriglio, Antonio | |
dc.date.accessioned | 2020-10-05T06:49:29Z | |
dc.date.available | 2020-10-05T06:49:29Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Bener, A., Dafeeah, E. E., Abou-Saleh, M. T., Bhugra, D. ve Ventriglio, A. (2020). Co-Morbidity between major depression and schizophrenia: Prevalence and clinical characteristics. Psychiatria Danubina, 32(1), 78-83. https://dx.doi.org/10.24869/psyd.2020.78 | en_US |
dc.identifier.issn | 0353-5053 | |
dc.identifier.uri | https://dx.doi.org/10.24869/psyd.2020.78 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/5902 | |
dc.description.abstract | Backround: The aim of this study was to explore the co-morbidity between Major Depressive Disorder (MDD) and Schizophrenia (SZ) among a large number of patients describing their clinical characteristics and rate of prevalence.Subjects and methods: A cohort-study was carried out on 396 patients affected by MDD and SZ who consecutively attended the Department of Psychiatry, Rumeilah Hospital in Qatar. We employed the World Health Organization - Composite International Diagnostic Interview (WHO-CIDI) and the Structured Clinical Interview for DSM-5 (SCID-5) for diagnoses. Patients were also grouped in MDD patients with and without co-morbid SZ (MDD vs MDD/SZ) for comparisons.Results: A total of 396 subjects were interviewed. MDD patients with comorbid SZ (146(36.8%)) were 42.69 +/- 14.33 years old whereas MDD without SZ patients (250 (63.2%)) aged 41.59113.59. Statistically significant differences between MDD with SZ patients and MDD without SZ patients were: higher BMI (Body Mass Index) (p=0.025), lower family income (p=0.004), higher rate of cigarette smoking (p<0.001), and higher level of consanguinity (p=0.023). Also, statistically significant differences were found in General Health Score (p=0.017), Clinical Global Impression-BD Score (p=0.042), duration of illnesses (p=0.003), and Global Assessment of Functioning (p=0.012). Rates of anxiety dimensions (e.g.: general anxiety, agoraphobia, somatisation, etc.), mood dimensions (e.g.: major depression, mania, oppositional defiant behaviour, Bipolar disorder), Attention Deficit Hyperactivity Disorder, psychotic and personality dimensions were higher among MDD with SZ patients than MDD without SZ.Conclusion: This study confirms that MDD with SZ is a common comorbidity especially among patients reporting higher level of consanguinity. MDD/SZ comorbidity presents unfavourable clinical characteristics and higher levels of morbidity at rating scales. | en_US |
dc.description.sponsorship | Qatar Diabetes Association, Qatar Foundation and partially Qatar National Research Fund-QNRF
Hamad Medical Corporation | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Medicinska Naklada | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Schizophrenia | en_US |
dc.subject | Major Depressive Disorder | en_US |
dc.subject | Co-Morbidity | en_US |
dc.subject | Consanguinity | en_US |
dc.title | Co-Morbidity between major depression and schizophrenia: Prevalence and clinical characteristics | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Psychiatria Danubina | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Halk Sağlığı Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-7902-5803 | en_US |
dc.identifier.volume | 32 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 78 | en_US |
dc.identifier.endpage | 83 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.24869/psyd.2020.78 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q3 | en_US |