• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   [email protected]
  • Fakülteler
  • Tıp Fakültesi
  • Makale Koleksiyonu
  • View Item
  •   [email protected]
  • Fakülteler
  • Tıp Fakültesi
  • Makale Koleksiyonu
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Evaluation of the synergy of ceftazidime/avibactam in combination with colistin, doripenem, levofloxacin, tigecycline, and tobramycin against OXA-48 producing enterobacterales

Thumbnail

View/Open

Tam Metin / Full Text (1.043Mb)

Access

info:eu-repo/semantics/embargoedAccess

Date

2020

Author

Mataracı Kara, Emel
Yılmaz, Mesut
İstanbullu Tosun, Ayşe
Özbek Çelik, Berna

Metadata

Show full item record

Citation

Mataracı Kara, E., Yılmaz, M., İstanbullu Tosun, A. ve Özbek Çelik, B. (2020). Evaluation of the synergy of ceftazidime/avibactam in combination with colistin, doripenem, levofloxacin, tigecycline, and tobramycin against OXA-48 producing enterobacterales. Journal of Chemotherapy, 32(4), 171-178. https://dx.doi.org/10.1080/1120009X.2020.1761172

Abstract

This study aims to analyze the effect of ceftazidime/avibactam plus various antibiotics against OXA-48-producing Enterobacterales isolated from Intensive Care Units. Seventy-four non-duplicate OXA-48-producing Enterobacterales isolates were screened for their MICs by the microbroth dilution method. The in-vitro bactericidal and synergistic activities of ceftazidime/avibactam alone or in combination with other antibiotics were determined by time-kill curve assays. According to our results, colistin was the most active drug with higher susceptibility rates in the strains. Colistin, levofloxacin, tobramycin, and doripenem showed bactericidal effects against different isolates. The best synergistic interactions were achieved with ceftazidime/avibactam + colistin, ceftazidime/avibactam + tobramycin, and ceftazidime/avibactam + tigecycline against studied strains used at 1xMIC concentrations at 24 h. No antagonism was observed against studied OXA-48-producing Enterobacterales strains. The findings of this study suggest that ceftazidime/avibactam plus colistin, tobramycin, or tigecycline were more effective against OXA-48-producing Enterobacterales strains. This combination therapy could be an alternative antibiotic therapy for carbapenemase-producing Enterobacterales strains.

WoS Q Kategorisi

Q4

Source

Journal of Chemotherapy

Volume

32

Issue

4

URI

https://dx.doi.org/10.1080/1120009X.2020.1761172
https://hdl.handle.net/20.500.12511/5627

Collections

  • Makale Koleksiyonu [2815]
  • PubMed İndeksli Yayınlar Koleksiyonu [3008]
  • Scopus İndeksli Yayınlar Koleksiyonu [4566]
  • WoS İndeksli Yayınlar Koleksiyonu [4889]



DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 




| Guide | Contact |

[email protected]

by OpenAIRE
Advanced Search

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsInstitution AuthorORCIDTitlesSubjectsTypeLanguageDepartmentCategoryWoS Q ValuePublisherAccess TypeThis CollectionBy Issue DateAuthorsInstitution AuthorORCIDTitlesSubjectsTypeLanguageDepartmentCategoryWoS Q ValuePublisherAccess Type

My Account

LoginRegister

Statistics

View Google Analytics Statistics

DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 


|| Instruction || Guide || Library || İstanbul Medipol University || OAI-PMH ||

Kütüphane ve Dokümantasyon Daire Başkanlığı, İstabul, Turkey
If you find any errors in content, please contact: [email protected]

Creative Commons License
[email protected] by İstanbul Medipol University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

[email protected]:


DSpace 6.2

tarafından İdeal DSpace hizmetleri çerçevesinde özelleştirilerek kurulmuştur.