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dc.contributor.authorYuluğ, Burak
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2020-07-17T08:55:27Z
dc.date.available2020-07-17T08:55:27Z
dc.date.issued2017en_US
dc.identifier.citationYuluğ, B., Hanoğlu, L. ve Kılıç, E. (2017). The neuroprotective effect of focused ultrasound: New perspectives on an old tool. Brain Research Bulletin, 131, 199-206. https://dx.doi.org/10.1016/j.brainresbull.2017.04.015en_US
dc.identifier.issn0361-9230
dc.identifier.issn1873-2747
dc.identifier.urihttps://dx.doi.org/10.1016/j.brainresbull.2017.04.015
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5544
dc.description.abstractIntroduction Transcranial focused ultrasound (tFUS) is a novel technique that can noninvasively modulate the cortical function. Moreover, there are rapidly replicating evidence suggesting the role of tFUS for targeted neuroprotective drug delivery by increasing the permeability of the central nervous system barrier that results with increased neuroprotective activity. In contrast to the indirect neuroprotective effect, there is rare evidence suggesting the direct parenchymal neuroprotective effect of transcranial focused ultrasound (tFUS). In the light of these findings, we aimed to review the direct and indirect neuroprotective effect of FUS in various animal models of Stroke, Parkinson's Disease, Alzheimer's Disease and Major Depressive Disorder.Methods: A literary search was conducted, utilizing search terms "animal", "focused ultrasound", "neuroprotection", "Alzheimer's Disease", "Parkinson's Disease ", "Stroke", "Neurodegenerative disease" and "Major Depressive Disorder". Items were excluded if they failed to: (1) include patients, (2) editorials, and letters.Results: This mini-review article presents an up-to-date review of the neuroprotective effects of tFUS in animal studies and suggests the dual neurotherapeutic role of tFUS in various neurodegenerative diseases.Conclusion: Future well-conducted human studies are emergently needed to assess the neuroprotective effects of FUS.en_US
dc.language.isoengen_US
dc.publisherPergamon-Elsevier Science Ltd.en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectFocused Ultrasounden_US
dc.subjectNeurodegenerative Diseaseen_US
dc.subjectNeuroprotectionen_US
dc.titleThe neuroprotective effect of focused ultrasound: New perspectives on an old toolen_US
dc.typereviewen_US
dc.relation.ispartofBrain Research Bulletinen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-9704-6173en_US
dc.authorid0000-0003-4292-5717en_US
dc.authorid0000-0001-6494-8923en_US
dc.identifier.volume131en_US
dc.identifier.startpage199en_US
dc.identifier.endpage206en_US
dc.relation.publicationcategoryDiğeren_US
dc.identifier.doi10.1016/j.brainresbull.2017.04.015en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ2en_US


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