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dc.contributor.authorYuluğ, Burak
dc.contributor.authorSchaebitz, Wolf-Ruediger
dc.date.accessioned2020-07-14T06:22:42Z
dc.date.available2020-07-14T06:22:42Z
dc.date.issued2017en_US
dc.identifier.citationYuluğ, B. ve Schaebitz, W.-R. (2017). Combination therapy with thrombolysis. Neuroprotective Therapy for Stroke and Ischemic Disease, 607-620. https://dx.doi.org/10.1007/978-3-319-45345-3_25en_US
dc.identifier.isbn9783319453453
dc.identifier.isbn9783319453446
dc.identifier.urihttps://dx.doi.org/10.1007/978-3-319-45345-3_25
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5475
dc.description.abstractThrombolysis is the most effective treatment for acute ischemic stroke representing the basic therapeutic standard in the western world. Novel drug treatments are therefore unlikely to be developed as stand-alone approaches and every novel treatment should be considered as combination treatment together with thrombolysis. Such a combination should exert synergistic actions together with t-PA, and probably even more important decrease the potential adverse effects of thrombolysis including reperfusion-related adverse effects such as cytotoxin and free radical release and toxicity as well as BBB degradation and subsequent hemorrhagic complications. Preclinical data show that this approach can make thrombolysis safer and buy time for later treatment initiation. At current, the clinical evidence for this approach is relatively weak, but a systematic translation of preclinical findings into the human situation is ongoing with some recent hopeful examples from clinical trials.en_US
dc.language.isoengen_US
dc.publisherSpringer International Publishing AGen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuroprotectionen_US
dc.subjectAcute Ischemic Strokeen_US
dc.subjectTissue Plasminogen Activatoren_US
dc.titleCombination therapy with thrombolysisen_US
dc.typearticleen_US
dc.relation.ispartofNeuroprotective Therapy for Stroke and Ischemic Diseaseen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0002-9704-6173en_US
dc.identifier.startpage607en_US
dc.identifier.endpage620en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/978-3-319-45345-3_25en_US


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