dc.contributor.author | Eğimezer, G. | |
dc.contributor.author | Üstündağ, Ünsal Veli | |
dc.contributor.author | Ateş, Perihan Seda | |
dc.contributor.author | Ünal, İsmail | |
dc.contributor.author | Üstündağ, F. D. | |
dc.contributor.author | Alturfan, Ahmet Ata | |
dc.contributor.author | Emekli-Alturfan, Ebru | |
dc.contributor.author | Adil Altınöz, Meriç | |
dc.contributor.author | Elmacı, İlhan | |
dc.date.accessioned | 2020-07-13T09:46:24Z | |
dc.date.available | 2020-07-13T09:46:24Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Eğimezer, G., Üstündağ, Ü. V., Ateş, P. S., Ünal, İ., Üstündağ, F. D., Alturfan, A. A. ... Elmacı, İ. (2020). Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish. Human and Experimental Toxicology, 39(7), 920-929. https://dx.doi.org/10.1177/0960327120905961 | en_US |
dc.identifier.issn | 0960-3271 | |
dc.identifier.issn | 1477-0903 | |
dc.identifier.uri | https://dx.doi.org/10.1177/0960327120905961 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/5466 | |
dc.description.abstract | Cancer continues to be a major cause of mortality globally. Zebrafish present suitable models for studying the mechanisms of genotoxic carcinogens. The aim of this study was to investigate the interaction between oxidant-antioxidant status, apoptosis and immunity in zebrafish that were exposed to three different genotoxic carcinogens methylnitrosourea, dimethylbenzanthracene, benzoapyrene and methylnitrosourea + dimethylbenzanthracene starting from early embryogenesis for 30 days. Lipid peroxidation, nitric oxide levels, superoxide dismutase and glutathione-S-transferase activities and mRNA levels of apoptosis genes p53, bax, casp3a, casp2 and immunity genes fas, tnf alpha and ifn gamma 1 were evaluated. The disruption of the oxidant-antioxidant balance accompanied by altered expressions of apoptotic and immunity related genes were observed in different levels according to the carcinogen applied. Noteworthy, ifn gamma expressions decreased in all carcinogen-exposed groups. Our results will provide basic data for further carcinogenesis research in zebrafish models. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SAGE Publications Ltd | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Methylnitrosourea | en_US |
dc.subject | Dimethylbenzanthracene | en_US |
dc.subject | Benzoapyrene | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Immunity | en_US |
dc.subject | Zebrafish | en_US |
dc.title | Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Human and Experimental Toxicology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-0804-1475 | en_US |
dc.identifier.volume | 39 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 920 | en_US |
dc.identifier.endpage | 929 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1177/0960327120905961 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q2 | en_US |