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dc.contributor.authorEğimezer, G.
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorAteş, Perihan Seda
dc.contributor.authorÜnal, İsmail
dc.contributor.authorÜstündağ, F. D.
dc.contributor.authorAlturfan, Ahmet Ata
dc.contributor.authorEmekli-Alturfan, Ebru
dc.contributor.authorAdil Altınöz, Meriç
dc.contributor.authorElmacı, İlhan
dc.date.accessioned2020-07-13T09:46:24Z
dc.date.available2020-07-13T09:46:24Z
dc.date.issued2020en_US
dc.identifier.citationEğimezer, G., Üstündağ, Ü. V., Ateş, P. S., Ünal, İ., Üstündağ, F. D., Alturfan, A. A. ... Elmacı, İ. (2020). Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish. Human and Experimental Toxicology, 39(7), 920-929. https://dx.doi.org/10.1177/0960327120905961en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.urihttps://dx.doi.org/10.1177/0960327120905961
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5466
dc.description.abstractCancer continues to be a major cause of mortality globally. Zebrafish present suitable models for studying the mechanisms of genotoxic carcinogens. The aim of this study was to investigate the interaction between oxidant-antioxidant status, apoptosis and immunity in zebrafish that were exposed to three different genotoxic carcinogens methylnitrosourea, dimethylbenzanthracene, benzoapyrene and methylnitrosourea + dimethylbenzanthracene starting from early embryogenesis for 30 days. Lipid peroxidation, nitric oxide levels, superoxide dismutase and glutathione-S-transferase activities and mRNA levels of apoptosis genes p53, bax, casp3a, casp2 and immunity genes fas, tnf alpha and ifn gamma 1 were evaluated. The disruption of the oxidant-antioxidant balance accompanied by altered expressions of apoptotic and immunity related genes were observed in different levels according to the carcinogen applied. Noteworthy, ifn gamma expressions decreased in all carcinogen-exposed groups. Our results will provide basic data for further carcinogenesis research in zebrafish models.en_US
dc.language.isoengen_US
dc.publisherSAGE Publications Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethylnitrosoureaen_US
dc.subjectDimethylbenzanthraceneen_US
dc.subjectBenzoapyreneen_US
dc.subjectAntioxidanten_US
dc.subjectApoptosisen_US
dc.subjectImmunityen_US
dc.subjectZebrafishen_US
dc.titleMethylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafishen_US
dc.typearticleen_US
dc.relation.journalHuman and Experimental Toxicologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.authorid0000-0003-0804-1475en_US
dc.identifier.volume39en_US
dc.identifier.issue7en_US
dc.identifier.startpage920en_US
dc.identifier.endpage929en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1177/0960327120905961en_US


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