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dc.contributor.authorKuyucu, Ersin
dc.contributor.authorÇabuk, Hüseyin
dc.contributor.authorGüler, Yasin
dc.contributor.authorKuşku Çabuk, Fatmagül
dc.contributor.authorKılıç, Erdinç
dc.contributor.authorBülbül, Murat
dc.date.accessioned2020-07-09T15:47:43Z
dc.date.available2020-07-09T15:47:43Z
dc.date.issued2020en_US
dc.identifier.citationKuyucu, E., Çabuk, H., Güler, Y., Kuşku Çabuk, F., Kılıç, E. ve Bülbül, M. (2020). Can intra-articular 1 alpha, 25-dihydroxyvitamin D3 administration be therapeutical in joint cartilage damage? Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca, 87(2), 90-94.en_US
dc.identifier.issn0001-5415
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5444
dc.description.abstractINTRODUCTION Vitamin D-deficiency is known to cause nerve conduction impairments, cancer and chronic diseases, as well as the pathogenesis of osteoarthritis. Our goal with this study is to evaluate the cartilage healing by applying intraarticular 1 alpha, 25 (OH) 2D3 at different doses in rats with normal vitamin D levels and metabolism, which we made focal chondral damage model in the knee joint. MATERIAL AND METHODS 35 male Sprague-Dawley rats aged 20-24 weeks were used in our study. Both knees of rats were cartilage defected surgically on day 0. Joint injections performed at 06:00 am on 0th and 2nd days and after second injection others performed on days 9-16 and 23 following a weekly period. RESULTS In the fourth week, hematoxylin eosin staining measurements showed statistically significant difference according to the groups (p < 0.01) Metalloproteinase-13 (MMP-13) in histological staining for evaluating cartilage healing and healing levels showed statistically significant differences between the groups at first week and fourth week (p < 0.05). DISCUSSION Vitamin D, which affects many tissues through its receptors, is believed to be chondroprotective and neuroprotective by decreasing the expression of MMP in cartilage fibroblast, macrophage, lymphocyte through its intracellular receptors. To the best of our knowledge, this is the first study known to be intraarticular use of 1 alpha, 25-dihydroxyvitamin D3. Our study has been found to be safe and successful in terms of weight, systemic PTH and 1 alpha, 25-dihydroxyvitamin D3 levels in rats during treatment as well as better healing of cartilage damage.en_US
dc.language.isoengen_US
dc.publisherGalen s.r.o.en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitamin D3 Receptoren_US
dc.subjectArticular Cartilageen_US
dc.subjectOrthopedicsen_US
dc.subjectNerve Conductionen_US
dc.titleCan intra-articular 1 alpha, 25-dihydroxyvitamin D3 administration be therapeutical in joint cartilage damage?en_US
dc.typearticleen_US
dc.relation.ispartofActa Chirurgiae Orthopaedicae et Traumatologiae Cechoslovacaen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0003-3976-9530en_US
dc.authorid0000-0001-6200-7433en_US
dc.identifier.volume87en_US
dc.identifier.issue2en_US
dc.identifier.startpage90en_US
dc.identifier.endpage94en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ3en_US


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