dc.contributor.author | Güleç, Mustafa | |
dc.contributor.author | Selvi, Yavuz | |
dc.contributor.author | Boysan, Murat | |
dc.contributor.author | Aydın, Adem | |
dc.contributor.author | Beşiroğlu, Lütfullah | |
dc.contributor.author | Ağargün, Mehmet Yücel | |
dc.date.accessioned | 2020-05-28T06:31:30Z | |
dc.date.available | 2020-05-28T06:31:30Z | |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Güleç, M., Selvi, Y., Boysan, M., Aydın, A., Beşiroğlu, L. ve Ağargün, M. Y. (2011). Ongoing or re-emerging subjective insomnia symptoms after full/partial remission or recovery of major depressive disorder mainly with the selective serotonin reuptake inhibitors and risk of relapse or recurrence: A 52-week follow-up study. Journal of Affective Disorders, 134(1-3), 257-265. https://dx.doi.org/10.1016/j.jad.2011.05.056 | en_US |
dc.identifier.issn | 0165-0327 | |
dc.identifier.issn | 1573-2517 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/5237 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.jad.2011.05.056 | |
dc.description.abstract | Background: Many patients who remit fully/partially or recover from an episode of major depression continue to suffer from sleep problems, mainly insomnia. Our study assesses the frequency and types of ongoing or re-emerging subjective insomnia symptoms and their relationship to subsequent depressive relapse or recurrence in a group of full/partial remitters or recoverers.Method: Sixty patients, 18 to 65 years of age, with current MDD defined using DSM-IV-TR criteria were participated in the study. They began a 24-week course of open-label acute plus continuation phase treatment mainly with SSRIs. Maintenance treatment was not planned for not affecting natural relapse or recurrence rates. All participants were evaluated by CGI-S, BDI, HAMD-17, PSQI, and ISI at weeks 0. 4, 12, 24, and 52.Results: Majority of the participants (83.33%) had subjective sleep disturbance, insomnia prior to relapse or recurrence. Repeated measures ANOVA was used to evaluate changes in scores of depression and sleep scales over time between recurred (N =12) and non-recurred groups (N = 48). Differences between means were calculated with post hoc Bonferroni comparison test. The changes in scores of entire clinical scales over time between recurred and non-recurred groups were statistically significant Limitations: The limitations of this study include the use of a relatively small, mostly young female sample and the lack of an objective sleep measure to corroborate self-report scales.Conclusions: Early recognition and treatment of disturbances of the sleep-wake cycle may be important for treatment and prevention of recurrence of depression. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Depression | en_US |
dc.subject | Sleep | en_US |
dc.subject | Insomnia | en_US |
dc.subject | Remission | en_US |
dc.subject | Relapse | en_US |
dc.subject | Recurrence | en_US |
dc.title | Ongoing or re-emerging subjective insomnia symptoms after full/partial remission or recovery of major depressive disorder mainly with the selective serotonin reuptake inhibitors and risk of relapse or recurrence: A 52-week follow-up study | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Affective Disorders | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı | en_US |
dc.identifier.volume | 134 | en_US |
dc.identifier.issue | 1-3 | en_US |
dc.identifier.startpage | 257 | en_US |
dc.identifier.endpage | 265 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.jad.2011.05.056 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |