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dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorSarıcaoğlu, Mevhibe
dc.contributor.authorToprak, Güven
dc.contributor.authorHelvacı Yılmaz, Nesrin
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2020-05-08T08:12:50Z
dc.date.available2020-05-08T08:12:50Z
dc.date.issued2020en_US
dc.identifier.citationHanoğlu, L., Sarıcaoğlu, M., Toprak, G., Helvacı Yılmaz, N. ve Yuluğ, B. (2020). Preliminary findings on the role of high-frequency (5Hz) rTMS stimulation on M1 and pre-SMA regions in Parkinson's disease. Neuroscience Letters, 724. https://doi.org/10.1016/j.neulet.2020.134837en_US
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2020.134837
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5214
dc.description.abstractIt has been already shown that the motor symptoms of the Parkinson's Disease (PD) have been improved with high frequency rTMS although there is no consensus on the most suitable target brain localization for a maximal therapeutic efficacy. Here, we aimed to compare the therapeutic effect of high frequency (5Hz) rTMS stimulation on primary motor cortex (M1) and pre-supplementary (pre SMA) regions in patients with PD who were still on pharmacological treatment. The study included right-hand dominant16 patients with PD (5 females, 11 males) with demographically and clinically similar characteristics which were randomly assigned to group 1 (n=8) and group 2 (n=8) and received left M1 and the left pre-SMA rTMS procedure, respectively. Total and sequential motor scores of the Unified Parkinson's Disease Rating Scale (UPDRSmotor) were applied to all patients at the baseline and the patients were re-evaluated under the same clinical conditions one week after the end of the sessions. Comparisons of the UPDRS-motor scores between two groups yielded significant improvements after the rTMS on pre-SMA compared to M1 (M1 p=0.14; pre-SMA p=0.01). which were especially significant for the bradykinesia (p=0.04) and axial score related items (p=0.01). This is the first study that shows the effect of rTMS on pre-SMA and it appears to be a promising option in the treatment of PD.en_US
dc.language.isoengen_US
dc.publisherElsevier Ireland Ltden_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectHigh Frequency Rtmsen_US
dc.subjectM1 Stimulationen_US
dc.subjectParkinson's Diseaseen_US
dc.subjectPre-SMA Stimulationen_US
dc.titlePreliminary findings on the role of high-frequency (5Hz) rTMS stimulation on M1 and pre-SMA regions in Parkinson's diseaseen_US
dc.typearticleen_US
dc.relation.journalNeuroscience Lettersen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Fizyoterapi Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, İMÜ Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-4292-5717en_US
dc.authorid0000-0001-7566-1063en_US
dc.authorid0000-0002-9704-6173en_US
dc.identifier.volume724en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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