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dc.contributor.authorBabiloni, Claudio
dc.contributor.authorBlinowska, Katarzyna Joanna
dc.contributor.authorBonanni, Laura
dc.contributor.authorCichocki, Andrzej
dc.contributor.authorDe Haan, Willem
dc.contributor.authorDel Percio, Claudio
dc.contributor.authorDubois, Bruno
dc.contributor.authorEscudero, Javier
dc.contributor.authorFernández, Alberto
dc.contributor.authorFrisoni, Giovanni Battista
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHajoś, Mihály
dc.contributor.authorHampel, Harald
dc.contributor.authorIfeachor, Emmanuel C.
dc.contributor.authorKilborn, Kerry W.
dc.contributor.authorKumar, Sanjeev
dc.contributor.authorJohnsen, Kristinn
dc.contributor.authorJohannsson, Magnus
dc.contributor.authorJeong, Jaeseung
dc.contributor.authorLebeau, Fiona E.N.
dc.contributor.authorLizio, Roberta
dc.contributor.authorLopes da Silva, Fernando H.
dc.contributor.authorMaestu, Fernando
dc.contributor.authorMcGeown, William Jonathan
dc.contributor.authorMckeith, Ian G.
dc.contributor.authorMoretti, Davide Vito
dc.contributor.authorNobili, Flavio Mariano
dc.contributor.authorOlichney, John
dc.contributor.authorOnofrj, Marco
dc.contributor.authorPalop, Jorge J.
dc.contributor.authorRowan, Michael
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorStruzik, Zbigniew Romuald
dc.contributor.authorTanila, Heikki
dc.contributor.authorTeipel, Stephan
dc.contributor.authorTaylor, John-Paul
dc.contributor.authorWeiergräber, Marco
dc.contributor.authorYener, Görsev
dc.contributor.authorYoung-Pearse, Tracy
dc.contributor.authorDrinkenburg, Wilhelmus H.
dc.contributor.authorRandall, Fiona
dc.date.accessioned2020-04-27T12:45:55Z
dc.date.available2020-04-27T12:45:55Z
dc.date.issued2020en_US
dc.identifier.citationBabiloni, C., Blinowska, K. J., Bonanni, L., Cichocki, A., De Haan, W., Del Percio, C. ... Randall, F. (2020). What electrophysiology tells us about Alzheimer's disease: A window into the synchronization and connectivity of brain neurons. Neurobiology of Aging, 85, 58-73. https://dx.doi.org/10.1016/j.neurobiolaging.2019.09.008en_US
dc.identifier.issn0197-4580
dc.identifier.issn1558-1497
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5206
dc.identifier.urihttps://dx.doi.org/10.1016/j.neurobiolaging.2019.09.008
dc.description.abstractElectrophysiology provides a real-time readout of neural functions and network capability in different brain states, on temporal (fractions of milliseconds) and spatial (micro, meso, and macro) scales unmet by other methodologies. However, current international guidelines do not endorse the use of electroencephalographic (EEG)/magnetoencephalographic (MEG) biomarkers in clinical trials performed in patients with Alzheimer's disease (AD), despite a surge in recent validated evidence. This position paper of the ISTAART Electrophysiology Professional Interest Area endorses consolidated and translational electrophysiological techniques applied to both experimental animal models of AD and patients, to probe the effects of AD neuropathology (i.e., brain amyloidosis, tauopathy, and neurodegeneration) on neurophysiological mechanisms underpinning neural excitation/inhibition and neurotransmission as well as brain network dynamics, synchronization, and functional connectivity, reflecting thalamocortical and corticocortical residual capacity. Converging evidence shows relationships between abnormalities in EEG/MEG markers and cognitive deficits in groups of AD patients at different disease stages. The supporting evidence for the application of electrophysiology in AD clinical research as well as drug discovery pathways warrants an international initiative to include the use of EEG/MEG biomarkers in the main multicentric projects planned in AD patients, to produce conclusive findings challenging the present regulatory requirements and guidelines for AD studies.en_US
dc.description.sponsorshipFrench National Research Agency (ANR)en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectThe Alzheimer's Association Internationalen_US
dc.subjectSociety to Advance Alzheimer's Research and Treatment (ISTAART)en_US
dc.subjectAlzheimer's Disease (AD)en_US
dc.subjectElectroencephalography and Magnetoencephalography (EEG and MEG)en_US
dc.subjectResting-State Conditionen_US
dc.subjectEvent-Related Potentials and Magnetic Fieldsen_US
dc.subjectPreclinical and Clinical Researchen_US
dc.titleWhat electrophysiology tells us about Alzheimer's disease: A window into the synchronization and connectivity of brain neuronsen_US
dc.typereviewen_US
dc.relation.ispartofNeurobiology of Agingen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalıen_US
dc.authorid0000-0002-0860-0524en_US
dc.identifier.volume85en_US
dc.identifier.startpage58en_US
dc.identifier.endpage73en_US
dc.relation.publicationcategoryDiğeren_US
dc.identifier.doi10.1016/j.neurobiolaging.2019.09.008en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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