dc.contributor.author | Batur, Şebnem | |
dc.contributor.author | Dülger, Onur | |
dc.contributor.author | Durak, Şermin | |
dc.contributor.author | Yumuk, Perran Fulden | |
dc.contributor.author | Çağlar, Hale Başak | |
dc.contributor.author | Bozkurtlar, Emine | |
dc.contributor.author | Bozkurt, Süheyla | |
dc.contributor.author | Taştekin, Ebru | |
dc.contributor.author | Çiçin, İrfan | |
dc.contributor.author | Ahiskalı, Rengin | |
dc.contributor.author | Çakır, Aslı | |
dc.contributor.author | Öz, Büge | |
dc.date.accessioned | 2020-03-23T06:16:12Z | |
dc.date.available | 2020-03-23T06:16:12Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Batur, Ş., Dülger, O., Durak, Ş., Yumuk, P. F., Çağlar, H. B., Bozkurtlar, E. ... Öz, B. (2020). Concordance of PD-L1 expression and CD8+ TIL intensity between NSCLC and synchronous brain metastases. Bosnian Journal of Basic Medical Sciences, 20(3), 329-335. https://doi.org/10.17305/bjbms.2019.4474 | en_US |
dc.identifier.uri | https://doi.org/10.17305/bjbms.2019.4474 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/5056 | |
dc.description.abstract | Programmed death-ligand 1 (PD-L1) is suggested to be a predictive biomarker in non-small-cell lung carcinoma (NSCLC). However, the differential expression of PD-L1 in primary lung tumor vs. synchronous metastases, especially brain metastasis (BM), remains unclear. This study assessed the concordance of PD-L1 expression on tumor cells and tumor-infiltrating lymphocytes (TILs) and CD8+ TIL intensity between primary lung tumors and synchronous BMs from 24 NSCLC patients. PD-L1, CD3, and CD8 positivity was determined by immunohistochemistry (IHC). PD-L1 scoring was based on the proportion of tumor cells with membranous expression of PD-L1 and the cutoff values <1%, 1–49%, and ≥50%. CD3 and CD8 positivity in TILs was evaluated semi-quantitatively and the proportion of CD3+/CD8+ TILs was determined. PD-L1 expression on tumor cells and TILs was evaluated in relation to CD3+/CD8+ TIL proportions and the intensity of CD8+ TILs between the paired primary lung and BM tissues. In the primary lung tumors, PD-L1 positivity was observed in 25%, 37.5%, and 37.5% cases for the cutoff values <1%, 1–49%, and ≥50%, respectively. PD-L1 expression on tumor cells was strongly correlated between the paired primary lung and BM tissues, in all cutoff groups. However, PD-L1 expression on TILs and the proportion of CD3+/CD8+ TILs were not strongly correlated in all three groups between the paired primary lung tumors and BMs. The intensity of CD8+ TILs was concordant in only 54.16% of the paired primary lung tumors and BMs. This study showed a high concordance of PD-L1 expression in neoplastic cells between primary NSCLC and synchronous BMs. | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Programmed Death-Ligand 1 | en_US |
dc.subject | Non-Small-Cell Lung Cancer | en_US |
dc.subject | NSCLC | en_US |
dc.subject | Tumor Immunology | en_US |
dc.subject | PD-L1 | en_US |
dc.subject | Brain Metastasis | en_US |
dc.subject | CD8 Lymphocytes | en_US |
dc.subject | Tumor Infiltrating Lymphocytes | en_US |
dc.subject | TILs | en_US |
dc.title | Concordance of PD-L1 expression and CD8+ TIL intensity between NSCLC and synchronous brain metastases | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Bosnian Journal of Basic Medical Sciences | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-0128-6947 | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 329 | en_US |
dc.identifier.endpage | 335 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.17305/bjbms.2019.4474 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q2 | en_US |