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dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorÇalışkan-Ak, Esin
dc.contributor.authorAteş, Perihan Seda
dc.contributor.authorÜnal, İsmail
dc.contributor.authorEğilmezer, Gizem
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorAlturfan, Ahmet Ata
dc.contributor.authorEmekli-Alturfan, Ebru
dc.date.accessioned2020-02-27T14:22:44Z
dc.date.available2020-02-27T14:22:44Z
dc.date.issued2019en_US
dc.identifier.citationÜstündağ, Ü. V., Çalışkan-Ak, E., Ateş, P. S., Ünal, İ., Eğilmezer, G., Yiğitbaşı, T. ... Emekli-Alturfan, E. (2019). White LED light exposure inhibits the development and xanthophore pigmentation of zebrafish embryo. Scientific Reports, 9(1). http://doi.org/10.1038/s41598-019-47163-yen_US
dc.identifier.issn2045-2322
dc.identifier.urihttp://doi.org/10.1038/s41598-019-47163-y
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4973
dc.description.abstractCircadian rhythm in all living organisms is disturbed continuously by artificial light sources and artificial lighting has become a hazard for public health. Circadian rhythm of melatonin maintains high levels of melatonin during the night and low levels during the day. N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) is one of the four enzymes required for melatonin synthesis and mtnr1ba is a melatonin receptor-encoding mRNA that is expressed widely in the embryonic brain. Pax7 has important roles during neural crest development and especially xanthophore pigmentation. Due to its diurnal nature, zebrafish provide a special opportunity for research on circadian rhythms that are regulated by melatonin. Here in this study, we showed that when compared with the white light control group, white LED light exposure resulted in loss of yellow pigmentation, decreased body length and locomotor activity, oxidant-antioxidant imbalance and decreased expressions of aanat2, mtnr1ba, and pax7 in zebrafish embryos. Histological analysis of this group revealed disorganization of the spaces among photoreceptor cells, decreased total retinal thickness and photoreceptor cell layer thickness compared with the control group. Artificial lighting pollution has the potential to become an important risk factor for different diseases including cancer especially for industrialized countries, therefore, more studies should be performed and necessary regulations should be made regarding this risk factor.en_US
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectDevelopmenten_US
dc.subjectXanthophore Pigmentationen_US
dc.subjectZebrafishen_US
dc.subjectWhite LED Light Exposureen_US
dc.titleWhite LED light exposure inhibits the development and xanthophore pigmentation of zebrafish embryoen_US
dc.typearticleen_US
dc.relation.ispartofScientific Reportsen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.authorid0000-0003-0804-1475en_US
dc.authorid0000-0002-0675-1839en_US
dc.identifier.volume9en_US
dc.identifier.issue1en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1038/s41598-019-47163-yen_US
dc.identifier.wosqualityQ1en_US
dc.identifier.scopusqualityQ1en_US


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