Bölüm "İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı" Scopus İndeksli Yayınlar Koleksiyonu için listeleme
Toplam kayıt 43, listelenen: 1-20
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An alternative approach to wound healing field; New composite films from natural polymers for Mupirocin dermal delivery
(Elsevier, 2019)In this study, novel adhesive films were prepared for Mupirocin dermal delivery. Natural polymers as chitosan, sodium alginate and carbopol were used for films development to evaluate possible interactions and drug release ... -
Assessment of aprotinin loaded microemulsion formulations for parenteral drug delivery: Preparation, characterization, in vitro release and cytotoxicity studies
(Bentham Science, 2016)The object of the current study was to prepare novel microemulsion formulations of aprotinin for parenteral delivery and to compare in vitro characteristics and release behaviour of different Technetium-99m (Tc-99m)-Aprotinin ... -
Azelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: Formulation, characterization, in vitro-ex vivo evaluation
(Taylor & Francis Ltd, 2022)In this study, hydrogels containing azelaic acid were developed using chitosan or HPMC (1-7%) for local treatment of acne vulgaris. Physicochemical properties such as viscosity, pH and mechanical properties were evaluated. ... -
Chitosan modification-enhanced silencing effect of Ad5-shPDGF-D vector in breast cancer cell line MDA-MB-231
(Bentham Science Publishers, 2023)Background: Gene therapeutics are being developed to treat metastatic breast tumors, which are mostly resistant to conventional therapies. Targeting platelet-derived growth factor-D (PDGF-D) is a viable approach because ... -
Chitosan-based buccal mucoadhesive bilayer tablets enhance the bioavailability of tizanidine hydrochloride by bypassing the first-pass metabolism
(2024)Tizanidine hydrochloride (TZN) is an antimuscarinic agent used in the treatment of pain-related spasms, multiple sclerosis, and stroke-related spasticity. It has low oral bioavailability (40 %) due to excessive first-pass ... -
Chitosan-based buccal mucoadhesive patches to enhance the systemic bioavailability of tizanidine
(Elsevier B.V., 2023)Tizanidine hydrochloride (TZN) is a muscle relaxant used to treat a variety of disorders such as painful muscle spasms and chronic spasticity. TZN has low oral bioavailability due to extensive first-pass metabolism and is ... -
Combination therapy with chitosan/siRNA nanoplexes targeting PDGF-D and PDGFR-beta reveals anticancer effect in breast cancer
(Wiley, 2023)Background: Platelet derived growth factors (PDGF)-D and the expression of its receptor increase in neoplastic progression of cancer. Co-silencing of growth factor and receptor can be suggested as an important strategy for ... -
Comparison of 3 doses of aloe vera and burn drugs in market on burnt rat models
(İstanbul Medipol University, 2018)Burn injuries are an incident that can have serious traumatic consequences. Degree of tissue damage depends on height of heat and duration of contact. It can be classified as 4 different burn degrees. Herbal treatments can ... -
Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet
(Marmara University, 2018)The oral application of drugs is the most popular route for achieving systemic effects, nevertheless, it is limited by difficulties related to physicochemical properties of the drug. Solid lipid nanoparticles (SLNs) are ... -
CORRECTION to: Clinical and demographic characteristics and two-year efficacy and safety data of 508 multiple sclerosis patients with fingolimod treatment (Archives of Neuropysychiatry, 60, 23)
(Turkish Neuropsychiatric Society, 2023)The name of the author Gökçe Sözer was mistakenly written as Gökçe Sezer. The correct name and institution are as follows. -
Current status of mucoadhesive gel systems for buccal drug delivery
(Bentham Science Publishers Ltd, 2021)Background: Buccal drug delivery is a fascinating research field. Gel-based formulations present potent characteristics as buccal systems since they have great physicochemical properties. Methods: Among the various gels, ... -
Design and characterization of nanocarriers loaded with Levofloxacin for enhanced antimicrobial activity; Physicochemical properties, in vitro release and oral acute toxicity
(Faculdade de Ciencias Farmaceuticas (Biblioteca), 2019)Inorganic and carbon based nanomaterials are widely used against several diseases, such as cancer, autoimmune diseases as well as fungi and bacteria colonization. In this work, Santa Barbara Amorphous mesoporous silica ... -
Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne
(Marmara University, 2024)Acne is an inflammatory or non-inflammatory disease that can be seen at every stage of human life and affects daily life both physically and psychologically. In the topical treatment of acne, substances with different ... -
Development and evaluation of mesoporous montmorillonite/magnetite nanocomposites loaded with 5-Fluorouracil
(Elsevier, 2020)Porous magnetic nanomaterials have attracted great attention in a variety of applications, particularly in the magnetically targeted and/or controlled release of various species. In this study, a new route was determined ... -
Development and in vitro evaluation of theophylline loaded matrix tablets prepared with direct compression
(Association of Pharmaceutical Teachers of India, 2016)The objectives of the present study are to develop novel sustained release matrix tablets of theophylline and to evaluate release properties and kinetic behaviour of these tablets. The formulations have been prepared in ... -
Development and validation of an HPLC method for voriconazole active substance in bulk and its pharmaceutical formulation
(Marmara University, 2016)The aim of the present study was to develop and validate a High-Performance Liquid Chromatography (HPLC) method for the determination of voriconazole in drug substances and in situ gel. A mixture of acetonitrile and ultrapure ... -
Effect of microemulsion formulation on biodistribution of Tc-99m-Aprotinin in acute pancreatitis models induced rats
(Taylor & Francis, 2016)Background: Aprotinin is a monomeric globular polypeptide, which derived from bovine lung tissue and theoretically attractive molecule in ameliorating the effects of acute pancreatitis. Acute pancreatitis is an inflammatory ... -
Effects of chitosan nanoparticles with long synthetic siRNAs targeting VEGF in triple-negative breast cancer cells
(Faculdade de Ciencias Farmaceuticas (Biblioteca), 2023)Vascular endothelial growth factor (VEGF) is an essential angiogenic factor in breast cancer development and metastasis. Small interfering RNAs (siRNAs) can specifically silence genes via the RNA interference pathway, ... -
Evaluation of in situ gel containing pycnogenol for cutaneous wound healing
(Logos Medical Publishing, 2019)Aim: Pycnogenol® (PYC) are used for various medicinal purposes. The aims of the present study were toevaluate wound healing activity of PYC loaded in situ gel in mice and to investigate its antibacterial activity.Method: ... -
Evaluation of the effect of honey-containing chitosan/hyaluronic acid hydrogels on wound healing
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)The 3D polymeric network structure of hydrogels imitates the extracellular matrix, thereby facilitating cell growth and differentiation. In the current study, chitosan/hyaluronic acid/honey coacervate hydrogels were produced ...